Publications by authors named "A Desbree"
Impact of respiratory pathogens detection by a rapid multiplex polymerase chain reaction assay on the management of community-acquired pneumonia for children at the paediatric emergency department. A randomized controlled trial, the Optimization of Pneumonia Acute Care (OPTIPAC) study.
Clin Microbiol Infect
January 2025
Article Synopsis
- The study examines whether rapid multiplex PCR testing in the emergency department can enhance the treatment of community-acquired pneumonia (CAP) in children compared to standard care.
- Conducted in 11 French centers between 2016-2018, the study included 499 children, with some receiving the PCR test and others only standard care, and tracked the effectiveness of initial antibiotic treatments over 15 days.
- Results showed a significant improvement in antibiotic treatment appropriateness in the PCR group, particularly reducing unnecessary antibiotics for viral pneumonia, indicating better antimicrobial stewardship without adverse effects.
Background: The progression of targeted radionuclide therapy requires the development of dosimetry software accounting for patient-specific biokinetics. New functionalities were thus developed in the OEDIPE software, to deal with multiple 3D images or multiple planar images and a SPECT image.
Materiel & Method: Methods were implemented to recover patient biokinetics in volumes of interest.
Molecular radiotherapy is the most used treatment modality against malign and benign diseases of thyroid. In that context, the large heterogeneity of therapeutic doses in patients and the range of effects observed show that individualized dosimetry is essential for optimizing treatments according to the targeted clinical outcome.We developed a high-resolution mobile gamma camera specifically designed to improve the quantitative assessment of the distribution and biokinetics ofI at patients's bedside after treatment of thyroid diseases.
View Article and Find Full Text PDFTo further improve the understanding ofbiological effects of incorporated radionuclides, it is essential to accurately determine cellular absorbed doses. In the case ofemitters, the cross-dose is a major contribution, and can involve up to millions of cells. Realistic and efficient computational models are needed for that purpose.
View Article and Find Full Text PDFRadiopharmaceutical dosimetry depends on the localization in space and time of radioactive sources and requires the estimation of the amount of energy emitted by the sources deposited within targets. In particular, when computing resources are not accessible, this task can be performed using precomputed tables of specific absorbed fractions (SAFs) or S values based on dosimetric models. The aim of the OpenDose collaboration is to generate and make freely available a range of dosimetric data and tools.
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