Publications by authors named "A Denise Savell"
Introduction: Aging rural veterans have limited access to geriatric mental health services. The establishment of Veterans Health Administration (VHA) regional telehealth hubs, or Clinical Resource Hubs (CRHs), has the potential to improve access to specialist care via telehealth delivered across healthcare systems within each VHA region. We used the Consolidated Framework for Implementation Research (CFIR 1.
View Article and Find Full Text PDFObjectives: Cross-facility tele-geriatric psychiatry consultation is a promising model for providing specialty services to regions lacking sufficient geriatric psychiatry expertise. This evaluation focused on assessing the feasibility and acceptability of a consultation program developed by a geriatric psychiatrist in a Veterans Health Administration regional telehealth hub.
Design: Concurrent, mixed methods program evaluation.
Article Synopsis
- Patients with smoldering multiple myeloma usually wait for their condition to get worse before starting treatment, but treating them early might help them live better.
- A study tested a combination of three medicines (elotuzumab, lenalidomide, and dexamethasone) on patients with a more serious form of the disease and looked at their blood samples to see how their immune cells changed.
- The results showed that early treatment was safe and might help, and how similar a patient’s immune system is to healthy people can help predict how well they will do with the treatment.
Two articles in this week’s issue focus on the use of ipilimumab and decitabine for patients with myelodysplasia (MDS) and acute myeloid leukemia (AML) before and after hematopoietic stem cell transplantation (HSCT) for high-risk disease. In the first article, Garcia et al report on the results of a phase 1 trial of the combination in 54 patients, demonstrating overall response rate of 52% in patients who are HSCT-naïve and 20% in patients post-HSCT; responses are usually short-lived. In the second article, Penter and colleagues characterize gene expression responses to therapy and conclude that decitabine acts directly to clear leukemic cells while ipilimumab acts on infiltrating lymphocytes in marrow and extramedullary sites.
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