Publications by authors named "A Demidem"
Background: The prevention and early screening of PCa is highly dependent on the identification of new biomarkers. In this study, we investigated whether plasma metabolic profiles from healthy males provide novel early biomarkers associated with future risk of PCa.
Methods: Using the (SU.
Introduction: Prostate cancer is a multifactorial disease whose aetiology is still not fully understood. Metabolomics, by measuring several hundred metabolites simultaneously, could enhance knowledge on the metabolic changes involved and the potential impact of external factors.
Objectives: The aim of the present study was to investigate whether pre-diagnostic plasma metabolomic profiles were associated with the risk of developing a prostate cancer within the following decade.
Non-Alcoholic Fatty Liver Disease (NAFLD) is considered as the forthcoming predominant cause for hepatocellular carcinoma (HCC). NAFLD-HCC may rise in non-cirrhotic livers in 40 to 50% of patients. The aim of this study was to identify different metabolic pathways of HCC according to fibrosis level (F0F1 vs.
View Article and Find Full Text PDFPurpose: Dietary intakes are reflected in plasma by the presence of hundreds of exogenous metabolites and variations in endogenous metabolites. The exploration of diet-related plasma metabolic profiles could help to better understand the impact of overall diet on health. Our aim was to identify metabolomic signatures reflecting overall diet in women from the French general population.
View Article and Find Full Text PDFArticle Synopsis
- - This study explores the link between diet and breast cancer risk by analyzing metabolites in the blood of women with breast cancer and matched controls, highlighting the importance of diet-related biomarkers for public health.
- - Researchers identified 595 candidate metabolites, narrowing down to 14 key compounds associated with breast cancer risk through advanced statistical methods, including a significant link with certain dietary patterns like a "Western" diet and specific food/drink intakes.
- - The findings suggest a metabolic signature involving compounds related to diet and gut health that could predict breast cancer risk, warranting further investigation in larger studies to broaden understanding and enhance early identification of at-risk women.