Publications by authors named "A Demetriou"
Article Synopsis
- * Results indicated a rise in breast and lung cancer rates, particularly among older adults, while prostate cancer incidence decreased for those aged 80 and over, and colorectal cancer rates remained stable.
- * Overall, there were significant improvements in 5-year net survival rates across all cancer types, prompting a call for enhanced efforts in cancer prevention and screening to further improve outcomes.
Bacillus Calmette-Guerin (BCG) is the primary treatment for non-muscle-invasive bladder cancer (NMIBC), known to stimulate inflammatory cytokines, notably interferon (IFN)-γ. We observed that prolonged IFN-γ exposure fosters adaptive resistance in recurrent tumors, aiding immune evasion and tumor proliferation. We identify HLA-E and NKG2A, part of a novel NK and T cell checkpoint pathway, as key mediators of resistance in BCG-unresponsive NMIBC.
View Article and Find Full Text PDFPurpose: Improved outcomes have been noted in patients undergoing malignant brain tumor resection at high-volume centers. Studies have arbitrarily chosen high-volume dichotomous cutoffs and have not evaluated volume-outcome associations at specific institutional procedural volumes. We sought to establish the continuous association of volume with patient outcomes and identify cutoffs significantly associated with mortality, major complications, and readmissions.
View Article and Find Full Text PDFArticle Synopsis
- The study examines how the loss of estrogen during menopause affects Alzheimer's disease (AD) and explores the role of estrogen receptor beta (ERβ) in providing neuroprotection, particularly concerning sex differences.
- Using a mouse model, researchers found that activating ERβ protects against cognitive decline and amyloid pathology in both male and female mice, although some gender-specific responses were noted.
- Ovariectomy increased certain types of amyloid beta in the brain but had limited overall effects, highlighting the need for further research into how ERβ functions differently in males and females regarding AD protection.