Central nervous system vasculitis in VEXAS syndrome: A rare involvemen.

Introduction: VEXAS (Vacuoles, E1 Enzyme, X-linked, autoinflammatory, Somatic) syndrome is a recently described severe adult-onset autoinflammatory disorder mediated by X-linked gene UBA1 somatic mutations, responsible of recurrent fever, skin involvement, chondritis, macrocytic anemia and inflammatory syndrome. Neurological manifestations are rarely described, and predominantly involve peripheral nervous system (PNS) impairment.

Results: We report the first central nervous system (CNS) vasculitis in VEXAS syndrome, characterized by headache, cognitive dysfunction and focal signs (cerebellar ataxia).

Focal pachymeningitis in a returning traveler: Don't forget melioidosis.

Background: Melioidosis is an endemic disease in South-East Asia and Northern Australia caused by a Gram-negative bacillus, . Manifestations are wide and neurological involvement have rarely been described.

Methods: In this paper, we report a patient returning from Asia with an unusual infection including CNS involvement consistent with a melioidosis.