Publications by authors named "A Delor"
Background: Patient registries are an important tool for networking medical caregivers and research, especially in the field of rare diseases. Individuals afflicted by multi-organ autoimmune diseases typically suffer from inflammation of multiple organs.
Project: GAIN (German genetic multi-organ Auto-Immunity Network) is the German network for research and therapy optimisation for individuals with congenital multi-organ autoimmune diseases.
A subcommittee of the Netherlands Commission on Radiation Dosimetry (NCS) was initiated in 2018 with the task to update and extend a previous publication (NCS-15) on the quality assurance of treatment planning systems (TPS) (Bruinvis2005). The field of treatment planning has changed considerably since 2005. Whereas the focus of the previous report was more on the technical aspects of the TPS, the scope of this report is broader with a focus on a department wide implementation of the TPS.
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- The NLRP3 inflammasome's activity, crucial for inflammation, is influenced by accessory proteins and different modifications, but the relationships among these factors are not fully understood.
- Research reveals that Bruton's tyrosine kinase (BTK), a key drug target, directly interacts with and phosphorylates NLRP3, impacting its regulation in immune cells.
- BTK enhances various aspects of NLRP3 activation, including its relocalization and assembly, suggesting that targeting BTK could be a new therapeutic strategy to control inflammation by regulating NLRP3 functions.
Article Synopsis
- This study investigates how small-gap plane-parallel ionization chambers respond to charge multiplication and proposes a method to accurately measure the product of recombination and charge multiplication correction factors (k).
- Experiments were conducted with IBA PPC05 chambers at various voltages using proton beams and Cobalt-60, focusing on Jaffé plots to analyze the data and compare it against theoretical models.
- Results show that while the charge multiplication effect is consistent across different beam qualities, it varies depending on the specific ionization chamber used, leading to recommendations for consistent operating voltages during calibration for accurate dosimetry.
Background And Purpose: There are several alternatives to the widespread ITV strategy in order to account for breathing-induced motion in PTV margins. The most sophisticated one includes the generation of a motion-compensated CT scan with the CTV placed in its average position - the mid-position approach (MidP). In such configuration, PTV margins integrate breathing as another random error.
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