Publications by authors named "A Delamarre"
Chromatin plays a pivotal role in genome expression, maintenance, and replication. To better understand chromatin organization, we developed a novel proximity-tagging method which assigns unique DNA barcodes to molecules that associate in 3D space. Using this method - Proximity Copy Paste (PCP) - we mapped the connectivity of individual nucleosomes in .
View Article and Find Full Text PDFBackground: Patients with advanced chronic liver disease (ACLD) are at high risk of developing hepatocellular carcinoma (HCC). Therefore, biannual surveillance is recommended. This large-scale multicenter study aimed to stratify the risk of HCC development in ACLD.
View Article and Find Full Text PDFArticle Synopsis
- Scientists studied a health problem called MASH, which affects people's livers, and worked on two tests to help doctors tell if someone has it.
- They looked at data from over 3,000 people to make sure their first test, called acMASH, worked well, and then created a new test called acFibroMASH to find more severe cases.
- The new acFibroMASH test was better at predicting who might have future liver problems compared to another test, showing it's a useful tool for doctors to keep patients healthy.
Dynamics of Liver Stiffness Measurement and Clinical Course of Primary Biliary Cholangitis.
Clin Gastroenterol Hepatol
December 2024
Article Synopsis
- The study investigates the prognostic value of changes in liver stiffness measurement (LSM) over time in patients with primary biliary cholangitis (PBC) who are being treated with ursodeoxycholic acid.
- It utilizes data from 3,078 patients over a 19-year period, finding that 59% of participants had an increase in LSM, which is linked to a higher risk of serious clinical events such as cirrhosis complications and liver transplants.
- The research concludes that monitoring LSM changes provides essential prognostic information, suggesting its potential as a valuable endpoint in clinical trials for PBC treatment.
Article Synopsis
- The study evaluated the accuracy of Agile scores (Agile 3+ and Agile 4) for diagnosing advanced liver fibrosis and cirrhosis in patients with metabolic dysfunction-associated steatotic liver disease (MASLD), alcohol-related liver disease (ALD), and chronic hepatitis B or C (CHB/C).
- It included 4,243 patients and found that Agile scores had diagnostic accuracy comparable to liver stiffness measurements (LSM) in MASLD and ALD, but performed less effectively in CHB/C.
- The results suggest that using Agile scores alongside existing biomarkers like FIB-4 can improve diagnosis by reducing indeterminate results and enhancing specificity for advanced liver conditions.