Correlation between parathyroid adenoma volume and perioperative outcomes in primary hyperparathyroidism: Does the size matter?

Background: Primary hyperparathyroidism (PHPT) due to a parathyroid adenoma stands as one of the most prevalent endocrinological disorders, with focused parathyroidectomy being the established therapeutic strategy.

Aim: This study aims to investigate whether the volume of the pathological gland influences perioperative outcomes and postoperative morbidity.

Methods: A retrospective analysis was conducted on data from 141 patients who underwent focused parathyroidectomy for PHPT at the University Hospital of Basel between 2007 and 2022.

E. Coli cytotoxic necrotizing factor-1 promotes colorectal carcinogenesis by causing oxidative stress, DNA damage and intestinal permeability alteration.

Background: Bacterial toxins are emerging as promising hallmarks of colorectal cancer (CRC) pathogenesis. In particular, Cytotoxic Necrotizing Factor 1 (CNF1) from E. coli deserves special consideration due to the significantly higher prevalence of this toxin gene in CRC patients with respect to healthy subjects, and to the numerous tumor-promoting effects that have been ascribed to the toxin in vitro.

bneR: A collaborative workflow for air pollution exposure modeling and uncertainty characterization using the Bayesian Nonparametric Ensemble.

Background: Air pollution is a major public health threat globally. Health studies, regulatory actions, and policy evaluations typically rely on air pollutant concentrations from single exposure models, assuming accurate estimations and ignoring related uncertainty. We developed a modeling framework, bneR, to apply the Bayesian Nonparametric Ensemble (BNE) prediction model that combines existing exposure models as inputs to provide air pollution estimates and their spatio-temporal uncertainty.

Integrated Spectral Sensitivity as Physics-Based Figure of Merit for Spectral Transducers in Optical Sensing.

The design of optical sensors aims at providing, among other things, the highest precision in the determination of the target measurand. Many sensor systems rely on a spectral transducer to map changes in the measurand into spectral shifts of a resonance peak in the reflection or transmission spectrum, which is measured by a readout device (e.g.