Retrospective evaluation of the effect of acid suppressant drugs on leukocyte ratios in dogs with mast cell tumors.

Background: Acid suppressant drugs (ASDs) are commonly used to decrease gastric acid production, but some evidence exists that ASDs exert immunomodulatory effects. Such an effect has not been investigated in dogs for which ASDs are routinely prescribed.

Hypothesis: Compared to naïve subjects, dogs treated with ASDs will exhibit differences in leukocyte ratios after treatment.

Biochemical, functional, and histopathologic characterization of lomustine-induced liver injury in dogs.

Objective: To characterize the biochemical, functional, and histopathologic changes associated with lomustine-induced liver injury in dogs.

Animals: I0 healthy purpose-bred sexually intact female hounds.

Procedures: Dogs were randomly assigned to receive lomustine (approx 75 mg/m, PO, q 21 d for 5 doses) alone (n = 5) or with prednisone (approx 1.

Evaluation of the agreement between a point-of-care lactate meter and a handheld laboratory analyzer in cats treated in emergency practice.

Objective: The purpose of this study was to determine if there was agreement between a new point-of-care (POC) lactate analyzer and a handheld laboratory analyzer when measuring blood lactate concentration in cats.

Design: Prospective observational study.

Setting: University veterinary teaching hospital.

Opportunistic Fungal Infections in Small Animals.

Opportunistic fungal infections have long been recognized as rare causes of disease in immunocompetent dogs and cats. Recently, the escalating use of multiagent immunosuppression protocols (especially those that include cyclosporine) has resulted in an increased number of patients with opportunistic fungal infection encountered by small animal practitioners and has altered the typical case phenotype. Based on histologic and cytologic features such as pigmentation, hyphal diameter, and distribution in tissue, these opportunistic mycoses can be placed into categories such as phaeohyphomycosis, hyalohyphomycosis, and eumycotic mycetoma.