Publications by authors named "A DeGazon Washington"
Background: SGLT-2i and GLP-1RA are recommended for persons with type 2 diabetes and atherosclerotic cardiovascular disease (ASCVD); for those prescribed, little is known about reasons for discontinuation.
Methods: From the COORDINATE-Diabetes randomized trial database, the frequency and reasons for discontinuation of SGLT2i or GLP-1RA were analyzed.
Results: 1045 participants were enrolled 7/2019 to 5/2022; 290 (27.
Progression of liver disease is dependent on intercellular signaling, including those mediated by extracellular vesicles (EVs). Within these EVs, microRNAs (miRNAs) are packaged to selectively silence gene expression in recipient cells for upregulating or downregulating a specific pathway. Injured hepatocytes secrete EV-associated miRNAs which can be taken up by liver sinusoidal endothelial cells, immune cells, hepatic stellate cells, and other cell types.
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- Platelets inherit RNA from their parent megakaryocytes and this study uses single-cell RNA sequencing to investigate the platelet transcriptome, which has not been thoroughly explored before.
- Findings revealed significant variability in gene expression among platelets, with common markers showing lower than expected abundance and highlighting that current identification methods often misclassify platelets.
- The research stresses the importance of specialized sequencing techniques for accurate platelet profiling, which could lead to advancements in understanding platelet biology and their potential use in immune therapy and as biomarkers for diseases like cancer.
Article Synopsis
- The study employs spin-echo small-angle neutron scattering (SESANS) to examine a wide range of structures in polymer-carbon nanocomposites, effectively covering length scales from 10 nm to 16 μm.
- The data processing incorporates a consistent method across two different SESANS instruments, producing reliable data that can be analyzed using established hierarchical models in software like SasView.
- This technique significantly enhances the ability to gather information about bulk structures, surpassing traditional scattering methods and opening new avenues for analyzing polymer nanocomposites across various scales.
Background: Postoperative maintenance fluids are traditionally provided via hypotonic dextrose containing fluids administered intravenously by continuous infusion. We hypothesized that scheduled weight-based boluses of balanced salt solution would be more physiologic, reduce fluid volumes, and improve patient comfort.
Methods: As part of an IRB-approved randomized controlled trial (Boluses of Ringer's in Surgical Kids, BRiSK), we randomized patients aged 1-21 years undergoing elective abdominal or thoracic surgery to post-operatively receive weight-based D0.