Endothelial cell alterations in capillaries of adipose tissue from patients affected by lipedema.

Objective: This study aimed to evaluate adipose tissue of lipedema patients.

Methods: Gluteo-femoral (affected area) and interscapular (nonaffected area) adipose tissue from 10 lean patients affected by lipedema stage 1 to 2 was studied and compared with tissue from 10 patients with obesity and 12 lean patients.

Results: The main features were alterations of capillaries with wall thickening (p ≤ 0.

A Study on the Oxidative Functionalization of a Poplar Biochar.

This study investigates the functionalization of a poplar biochar (PB), obtained by high-temperature pyrolysis, under oxidative conditions typically used in organic synthesis. In particular, concentrated nitric acid, a sulfonitric mixture and a piranha mixture were applied as oxidants at different temperatures and reaction times. In order to assess the outcome of the reaction conditions on the characteristics of the resultant products, these were characterized by a combination of imaging (SEM), spectroscopic (ATR-FTIR, RAMAN) and FFC-NMR relaxometric techniques.

The effects of SGLT2 inhibitors on metabolic phenotype and FGF-21 expression from the adipose tissue and the liver are less pronounced in ob/ob mice.

Background: the metabolic effects of sodium-glucose cotransporter-2 inhibitors (SGLT2i), such as lipolysis and ectopic fat reduction, seem related to the synthesis of fibroblast growth factor-21 (FGF-21), and FGF-21 analogs are now under investigation for the treatment of obesity complications such as metabolic dysfunction-associated steatotic liver disease. However, FGF-21 levels are paradoxically higher in obesity, indicating a hormone-resistant state that may hinder the benefits of SGLT2i.

Methods: To define if a different energy status influences the response to SGLT2i, we evaluated the effects of dapagliflozin administration on nine-week-old C57BL/6J wild-type and B6.

Comments on "Smoking patterns and outcomes of severe SARS-CoV-2 infection: a retrospective cohort study".

Dear Editor, We have read with interest the recently published paper by Beronja et al. reporting the clinical outcomes in a group of patients hospitalized for COVID-19 being current smokers or not and concluding that a history of cigarette smoking (past or active) is an independent factor for negative prognosis in COVID-19 patients..

Growth Hormone Increase Induced by Oral Administration of Melatonin in a Young Woman With Sleep Disturbances.

Growth hormone (GH) secretion by the pituitary is regulated by stimulatory and inhibitory pathways such as growth hormone releasing hormone (GHRH) and somatostatin, respectively, being also modulated by different neurotransmitters acting at the hypothalamic/pituitary level. The pineal gland hormone melatonin regulates GH secretion in many mammals, including humans, although its role in modulating GH secretion has been debated. We describe the case of a young woman chronically taking melatonin for sleep disturbances, referring to her general practitioner for flushing that appeared just after starting melatonin intake.