Publications by authors named "A De Sol"
The successful use of human induced pluripotent stem cells (iPSCs) for research or clinical applications requires the development of robust, efficient, and reproducible cryopreservation protocols. After cryopreservation, the survival rate of iPSCs is suboptimal and cell line-dependent. We assessed the use of ice recrystallization inhibitors (IRIs) for cryopreservation of human iPSCs.
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- Single-cell RNA sequencing (RNAseq) struggles to accurately determine gene expression due to factors like genetic variation, environmental influences, and gene length.
- Existing methods fall short because they overlook the unique expression patterns of different genes.
- The new method, scGeneXpress, uses gene-specific reference distributions to effectively identify expressed genes and enhances the analysis of single-cell RNAseq data across various human and mouse tissues.
Article Synopsis
- Scientists are exploring different ways to make cells younger, but current methods only help with a few parts of the cells.
- They created a tool called SINGULAR that helps understand how these rejuvenation methods work in detail, focusing on single cells in different body organs.
- By studying this, they found important signals that could help improve how our cells age, suggesting that using a mix of these signals could lead to better overall health.
Background: Bats are recognized as the natural reservoir of several zoonotic viruses that pose a threat to public health worldwide. In our recent reports we describe the identification of a novel poxvirus, IsrRAPXV, in Egyptian fruit bats. This poxvirus is associated with high morbidity and mortality in bats.
View Article and Find Full Text PDFThe retina is exquisitely patterned, with neuronal somata positioned at regular intervals to completely sample the visual field. Here, we show that phosphatase and tensin homolog (Pten) controls starburst amacrine cell spacing by modulating vesicular trafficking of cell adhesion molecules and Wnt proteins. Single-cell transcriptomics and double-mutant analyses revealed that Pten and Down syndrome cell adhesion molecule Dscam) are co-expressed and function additively to pattern starburst amacrine cell mosaics.
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