Publications by authors named "A De Lauzanne"
Effect of decentralising childhood tuberculosis diagnosis to primary health centre versus district hospital levels on disease detection in children from six high tuberculosis incidence countries: an operational research, pre-post intervention study.
EClinicalMedicine
April 2024
Article Synopsis
- Childhood tuberculosis (TB) is often underdiagnosed due to low awareness and limited access to necessary diagnostic tools in healthcare settings.
- An operational research study in several African and Asian countries tested a comprehensive diagnostic approach by decentralizing TB diagnostics to district hospitals and primary health centers for children under 15 years old.
- The intervention significantly increased TB detection rates, with diagnoses rising from 0.08% pre-intervention to 0.23% during the intervention, highlighting the effectiveness of decentralized health services.
Article Synopsis
- In places like Cambodia, where sanitation is poor, bacteria can easily spread between humans and animals, worsening the problem of antibiotic resistance.
- The study found similar patterns of antibiotic resistance in humans and animals in Cambodia, highlighting the need for better control at the human-animal interface to combat this issue effectively, particularly in lower and middle-income countries.
Background: Antibiotic resistance is a global public health issue, particularly in low- and middle-income countries (LMICs), where antibiotics required to treat resistant infections are not affordable. LMICs also bear a disproportionately high burden of bacterial diseases, particularly among children, and resistance jeopardizes progress made in these areas. Although outpatient antibiotic use is a major driver of antibiotic resistance, data on inappropriate antibiotic prescribing in LMICs are scarce at the community level, where the majority of prescribing occurs.
View Article and Find Full Text PDFBackground: The exact timing, causes, and circumstances of stillbirth and neonatal mortality in low- and middle-income countries (LMICs) remain poorly described, especially for antenatal stillbirths and deaths occurring at home. We aimed to provide reliable estimates of the incidence of stillbirth and neonatal death in three LMICs (Madagascar, Cambodia and Senegal) and to identify their main causes and associated risk factors.
Methods: This study is based on data from an international, multicentric, prospective, longitudinal, community-based mother-infant cohort.
Background: Vaccination reduces mortality from infectious disease, which is the leading cause of death in children under 5 and bears a particularly high burden in low- and middle-income countries. The Global Vaccine Action Plan (2011-2020) has set a target of 90% vaccine coverage for all vaccines included in national immunization programs by 2020. The objectives of this study were to estimate vaccine coverage among children in Madagascar, Cambodia, and Senegal and to identify the risk factors associated with incomplete vaccination.
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