Publications by authors named "A De Grazia"
Article Synopsis
- Hepcidin is a hormone linked to iron regulation, produced by colorectal cancer (CRC) cells, and this study investigates its potential as a prognostic biomarker in microsatellite stable (MSS) metastatic CRC (mCRC).
- The research found that mCRC patients with serum hepcidin levels over 40 ng/mL had a significantly lower one-year overall survival rate compared to those with lower levels, indicating a strong link between high hepcidin levels and poorer prognosis.
- Multivariate analysis confirmed that baseline serum hepcidin levels independently predict overall survival in MSS mCRC patients, suggesting it could be a useful marker for assessing treatment outcomes, warranting further research for validation.
Article Synopsis
- - Managing rare metastatic sites in solid tumors is tough due to a lack of guidelines, leading to generally poor patient outcomes.
- - A 75-year-old man developed severe nosebleeds from a nasopharyngeal metastasis linked to previous lung adenocarcinoma; this was confirmed via imaging and biopsy, and he responded well to radiation therapy.
- - Effective treatment relies on careful monitoring, precise imaging, and collaborative medical efforts, with radiation therapy being crucial for managing symptoms in these atypical cases.
Introduction: Neoadjuvant therapy (NAT) should increase the rate of breast-conserving surgery (BCS) in non-metastatic breast cancer (BC) patients, especially in those achieving tumor shrinkage. Still, the conversion from a pre-planned mastectomy to BCS in patients responding to NAT is not a widespread standard. We aimed to identify factors influencing surgical choices in this setting.
View Article and Find Full Text PDFInteractions between colorectal cancer (CRC) cells and the noncancerous cells in the tumor microenvironment (TME) induce mechanisms for the escape of tumor cells from immune attack. Hepcidin, a peptide that controls immune cell functions, is overproduced by CRC cells. This study aimed to evaluate whether hepcidin acts as a regulator of anti-tumor immunity in CRC.
View Article and Find Full Text PDFBackground And Aim: Bromodomain-containing protein 4 (BRD4), one of the components of the bromodomain and extraterminal domain (BET) family, is a transcriptional and epigenetic regulator of cellular proliferation and cytokine production. In this study, we assessed whether BRD4 regulates the cytokine response in inflammatory bowel diseases (IBD).
Materials And Methods: BRD4 expression was analyzed in intestinal mucosal samples of patients with ulcerative colitis (UC), patients with Crohn's disease (CD), normal controls (CTRs), and mice with chemically-induced colitis by real-time PCR, Western blotting, and confocal microscopy.