Publications by authors named "A De Grandi"
How does an autism diagnosis impact a child and their carer in regional Australia?
J Paediatr Child Health
November 2024
Aim: Autism spectrum disorder (ASD) is a common neurodevelopmental disorder. This study aims to investigate the impact of an ASD diagnosis on children and their carers from a regional/rural Australian perspective.
Methods: A three-part survey development study included: (i) Semi-structured individual ASD carer interviews to identify common themes; (ii) survey development and testing; and (iii) online survey circulation to wider group of carers, for data collection and analysis.
Article Synopsis
- - Researchers developed new ALK5 inhibitors aimed at treating diseases like cancer and fibrosis, focusing on a specific chemical structure called a 4,6-disubstituted pyridazine core.
- - They used a method called "scaffold-hopping" to explore different chemical frameworks and found a particularly effective compound that was enhanced for inhalation, reducing the risk of side effects.
- - The optimized ALK5 inhibitors demonstrated improved effectiveness and properties for lung retention, suggesting they could be good candidates for creating new inhaled treatment options.
Article Synopsis
- Idiopathic Pulmonary Fibrosis (IPF) primarily affects older individuals, but most research has been done using young mice; this study aimed to create an animal model that better represents older patients with IPF.* -
- The researchers induced pulmonary fibrosis in aged mice with a reduced dose of bleomycin, ensuring no significant mortality while monitoring lung health through micro-CT imaging and analyzing results through post-mortem histology.* -
- Findings showed that aged mice had worse lung function and more inflammation than younger ones, but treatment with Nintedanib significantly improved their condition, highlighting the importance of using appropriate models for drug testing and understanding IPF in older patients.*
Article Synopsis
- - Transfemoral access (TFA) is an effective alternative to upper extremity access (UEA) for branched endovascular aortic repair (bEVAR), but it poses risks of reduced blood flow in the lower limbs due to the large introducer sheaths used during the procedure.
- - A study involving 24 patients assessed lower limb blood flow during TFA-bEVAR by measuring ankle blood pressure and toe pulse oximetry before and after sheath insertions, revealing significant improvements in limb perfusion when downsizing the sheath from 10F to 14F.
- - The results showed a reduction in limb perfusion reduction (LPR) from 87.5% after the main body delivery system placement
Article Synopsis
- The study investigates the relationship between serum calcium levels and ventricular repolarization time, specifically the QT and JT intervals, which are important for heart health.
- Researchers conducted large-scale genome-wide analyses to explore potential interactions between calcium levels and genetic variants associated with QT and JT intervals, using over 122,000 participants.
- The results showed limited evidence for the hypothesized calcium interaction effects, suggesting that other factors, such as rare genetic variations or environmental influences, likely play a larger role in the unexplained heritability of QT and JT intervals.