Cefiderocol Resistance Conferred by Plasmid-Located Ferric Citrate Transport System in KPC-Producing Klebsiella pneumoniae.

Cefiderocol (FDC), a siderophore-cephalosporin conjugate, is the newest option for treating infection with carbapenem-resistant gram-negative bacteria. We identified a novel mechanism contributing to decreased FDC susceptibility in Klebsiella pneumoniae clinical isolates. The mechanism involves 2 coresident plasmids: pKpQIL, carrying variants of bla carbapenemase gene, and pKPN, carrying the ferric citrate transport (FEC) system.

Analysis of lifespan across Diversity Outbred mouse studies identifies multiple longevity-associated loci.

Lifespan is an integrative phenotype whose genetic architecture is likely to highlight multiple processes with high impact on health and aging. Here, we conduct a genetic meta-analysis of longevity in Diversity Outbred (DO) mice that includes 2,444 animals from three independently conducted lifespan studies. We identify six loci that contribute significantly to lifespan independently of diet and drug treatment, one of which also influences lifespan in a sex-dependent manner, as well as an additional locus with a diet-specific effect on lifespan.

Development of a multilocus sequence typing scheme.

Introduction: The genus is assuming greater clinical relevance among infections caused by also because of its intrinsic and acquired resistance to last-resort antibiotics. However, despite having been known and studied for over 50 years, genomics and taxonomy of the genus are currently undergoing a deep rearrangement. In this study we aim to outline and characterized the species.

Effects of bioformulation prototype and bioactive extracts from spent mushroom substrate on controlling of L.

Introduction: Food security and waste management represent the main challenges that need to be addressed in the near future. The use of bioformulations and bioactive compounds obtained from agricultural wastes could represent some of the solutions for the management of soil-borne pathogens.

Methods: In the present study, strain AP1, tested in oil dispersion (OD) formulation prototype and bio-extracts [hot water extract (HWE) and warm water extract (WWE)] derived from spent mushroom substrate (SMS) of , was tested as sustainable strategies to manage of lettuce.