Publications by authors named "A De Chiara"
Training and temporally validating an NTCP model of acute toxicity after whole breast radiotherapy, including the impact of advanced delivery techniques.
Radiother Oncol
December 2024
Purpose: The aim is to train and validate a multivariable Normal Tissue Complication Probability (NTCP) model predicting acute skin reactions in patients with breast cancer receiving adjuvant Radiotherapy (RT).
Methods And Materials: We retrospectively reviewed 1570 single-institute patients with breast cancer treated with whole breast irradiation (40 Gy/15fr). The patients were divided into training (n = 878, treated with 3d-CRT, from 2009 to 2017) and validation cohorts (n = 692, treated from 2017 to 2021, including advanced RT techniques).
Introduction: Chemoradiotherapy in head and neck cancer patients has a curative intent but often deteriorates nutritional status leading to sarcopenia and cachexia.
Methods: In this observational and single-centered study, a prospective evaluation of several biochemical and anthropometrical parameters, weight loss, handgrip strength, visual analogue scale of appetite, questionnaires associated with malnutrition & quality of life and body composition (obtained by Bioelectrical Impedance Vector Analysis) was performed before and after high-dose cisplatin chemotherapy combined with radiotherapy in 60 patients affected by head and neck cancer. Oral nutritional supplements were used to reach the correct number of daily calories and proteins.
Article Synopsis
- This study looked at how effective the bivalent mRNA COVID-19 vaccine is against serious infections during the omicron wave of the pandemic.
- It found that older individuals who were unvaccinated were nearly six times more likely to experience critical infections than those who were vaccinated.
- The results suggest that the bivalent vaccine significantly lowers the risk of severe disease from the omicron variant, especially for older adults, and more research is needed on booster shots' effectiveness.
Primary Ductal Her-2 Positive Adenocarcinoma of Salivary Gland: A Long Follow-Up Case Report and Review of the Literature.
Case Rep Ophthalmol Med
September 2024
Article Synopsis
- * The study presents a case of a 42-year-old woman with HER-2 positive primary ductal adenocarcinoma, detailing her treatment journey, which included surgery, radiotherapy, chemotherapy, and targeted therapy, leading to a favorable outcome.
- * The report highlights the importance of early diagnosis and a multimodal treatment approach for such aggressive tumors, emphasizing the need for documenting individual cases to improve patient management.
Most patients with Primary Mediastinal B-Cell Lymphoma (PMBCL) are cured by rituximab and doxorubicin-based immunochemotherapy, with or without radiotherapy. In cases with relapsed and refractory (RR) disease the prognosis was historically poor. Recently, immune checkpoint-based strategies have been shown to be highly effective in patients with RR-PMBCL.
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