Publications by authors named "A Davila T"
The cholinergic deficits and amyloid beta (Aβ) aggregation are the mainstream simultaneously observed pathologies during the progression of Alzheimer's disease (AD). Deposited Aβ plaques are considered to be the primary pathological hallmarks of AD and are contemplated as promising diagnostic biomarker. Herein, a series of novel theranostic agents were designed, synthesised and evaluated against cholinesterase (ChEs) enzymes and detection of Aβ species, which are major targets for development of therapeutics for AD.
View Article and Find Full Text PDFConcern about radiation exposure to non-human biota and the environment has increased since the 1990s, resulting in several publications by UNSCEAR, IAEA, ICRP, among other agencies, which highlighted significant gaps in knowledge regarding non-human biota and resulted in the establishment of Reference Animals and Plants (RAPs). In Brazil, the Atlantic Forest biome has vast biodiversity, but there is a lack of information on the radiometric profile of plant species growing there. Thus, the objective of this study was to evaluate the radiometric profile of Ouratea miersii (Malpighiales), endemic to the Atlantic Rainforest, collected in the State of Rio de Janeiro, city of Niterói, at the Municipal Natural Park (PARNIT), which covers a region of protected Atlantic Rainforest.
View Article and Find Full Text PDFSystemic lupus erythematosus (SLE) is an intricate autoimmune disease characterized by its impact on various organ systems, presenting with a wide range of clinical manifestations such as hematologic, neuropsychiatric, mucocutaneous, serosal, musculoskeletal, immunologic, cardiac, pleuropulmonary, and renal symptoms. Although its etiology is primarily autoimmune, various triggers, such as pregnancy, certain drugs, and infections, can result in "flares" with frequent relapses. Although more common in females, SLE is not uncommon in males, with a significant proportion experiencing a high disease burden.
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- Anorectal diseases pose significant health challenges, particularly complex conditions like fistula-in-ano, which can recur even after surgical interventions, especially if not fully treated.
- This report discusses a rare case of a complex anal fistula that communicated with the prostate gland, causing discomfort and pus discharge; after Ayurvedic treatment known as Ksharasutra, significant healing occurred.
- Following 4 months of treatment, the patient showed complete resolution of symptoms and no evidence of the fistula on follow-up imaging, demonstrating the effectiveness of Ksharasutra therapy without damaging anal sphincter function.
Article Synopsis
- * The study focused on using Au-WS nanohybrids, which combined gold nanoparticles with WS nano-flakes to significantly boost Raman signals, achieving enhancement factors (EF) of around 1.80 × 10 for analytes like R6G.
- * The research demonstrated the potential of these nanohybrids for highly sensitive detection, successfully identifying the ATCC 35218 bacterial strain at a concentration of 10 CFU/mL, which could lead to innovative biosensor developments for public health applications.