A 'Temple of Liberty'? Alexander von Humboldt and the French Revolution.

This article sheds new light on Alexander von Humboldt's political position in the revolutionary decade between 1789 and 1799. The young naturalist interacted with both supporters and opponents of the revolution. In July 1790, he even participated in the preparations for the Festival of the Federation in Paris together with Georg Forster.

Humboldtian Science and Humboldt's science.

This article investigates why Humboldtian Science, as a heuristic concept, has gained prominence in the historiography of science and requires clarification. It offers an ideal-type model of comparative research and exact measurements across vast spaces, which Susan F. Cannon and others tied to Alexander von Humboldt (1769-1859).

The adhesion GPCR and PCP component flamingo (FMI-1) alters body size and regulates the composition of the extracellular matrix.

The extracellular matrix (ECM) is a network of macromolecules that presents a vital scaffold for cells and enables multiple ways of cellular communication. Thus, it is essential for many physiological processes such as development, tissue morphogenesis, homeostasis, the shape and partially the size of the body and its organs. To ensure these, the composition of the ECM is tissue-specific and highly dynamic.

Integrated circulating tumour DNA and cytokine analysis for therapy monitoring of ALK-rearranged lung adenocarcinoma.

Background: Detection of circulating tumour DNA (ctDNA) in biological fluids is a minimally invasive alternative to tissue biopsy for therapy monitoring. Cytokines are released in the tumour microenvironment to influence inflammation and tumorigenic mechanisms. Here, we investigated the potential biomarker utility of circulating cytokines vis-à-vis ctDNA in ALK-rearranged+ lung adenocarcinoma (ALK + NSCLC) and explored the optimal combination of molecular parameters that could indicate disease progression.

Tumor Microenvironment in Pancreatic Intraepithelial Neoplasia.

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive tumors with a poor prognosis. A characteristic of PDAC is the formation of an immunosuppressive tumor microenvironment (TME) that facilitates bypassing of the immune surveillance. The TME consists of a desmoplastic stroma, largely composed of cancer-associated fibroblasts (CAFs), immunosuppressive immune cells, immunoregulatory soluble factors, neural network cells, and endothelial cells with complex interactions.