Publications by authors named "A Daugschies"

Article Synopsis
  • Toxoplasma gondii is a widespread parasite that can severely affect fetal brain development, leading to major disorders.
  • In an experiment, pregnant guinea pigs were infected with T. gondii, revealing that the parasite targets and infects various brain cells, including neural progenitor cells, neurons, and astrocytes.
  • The study found a significant reduction in both neuron and neural progenitor cell counts, highlighting impaired neurogenesis as a key issue in infected fetuses, and also identified microgliosis linked to the presence of T. gondii in the brain.
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The protozoan Toxoplasma gondii (T. gondii) is a zoonotic disease agent causing systemic infection in warm-blooded intermediate hosts including humans. During the acute infection, the parasite infects host cells and multiplies intracellularly in the asexual tachyzoite stage.

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Both and are common apicomplexan parasites in chickens. Host cell invasion by both protozoans includes gliding motility, host cell attachment and active penetration. Chicken macrophages as phagocytic cells participate in the innate host immune response against these two parasites.

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Background: is a frequent intestinal pathogen of chickens, causing economic impact on the poultry industry. is a neglected parasite in chickens. However, because of its zoonotic potential, poultry cryptosporidiosis may pose a risk to public health.

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Radiation-attenuated intracellular parasites are promising immunization strategies. The irradiated parasites are able to invade host cells but fail to fully replicate, which allows for the generation of an efficient immune response. Available radiation technologies such as gamma rays require complex shielding constructions and are difficult to be integrated into pharmaceutical production processes.

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