Publications by authors named "A Dascalu"
Chirality plays a crucial role in the pharmacological activity of triazoles, a key scaffold in antifungal agents and various therapeutic applications. This study focuses on optimizing the enantiomeric resolution of chiral triazoles using supercritical fluid chromatography (SFC) and 10 different columns, either immobilized or coated, chlorinated or nonchlorinated, cellulose or amylose-based chiral stationary phases (CSPs). Four novel triazoles and two marketed ones (tebuconazole and hexaconazole) were separated to determine optimal resolution conditions.
View Article and Find Full Text PDFCOPA Syndrome-From Pathogenesis to Treatment.
Diagnostics (Basel)
December 2024
Coatomer subunit α (COPA) syndrome is a mendelian autosomal dominant immune dysregulation disease characterized by early onset lung disease in the form of diffuse alveolar hemorrhaging or interstitial lung disease, frequently associated with arthritis, glomerulonephritis, and high titer autoantibodies usually mimicking other autoimmune diseases. While immunosuppressive medication has been effective in controlling arthritis, data on long-term lung disease control remains scarce, which poses a real challenge as the progression of lung disease is the main cause of poor life expectancy in COPA patients. Nevertheless, JAK inhibitor therapy seems to be the most promising therapeutic choice now.
View Article and Find Full Text PDFArticle Synopsis
- - Overlap syndrome of systemic sclerosis and idiopathic inflammatory myopathies is becoming more common, but its link with immune-mediated necrotizing myositis is not well-documented, requiring careful differentiation for proper treatment and prognosis.
- - Anti-signal recognition particle (anti-SRP) antibodies are crucial in diagnosing immune-mediated necrotizing myopathy, causing muscle damage and weakness, while their relationship with cardiac issues remains inconclusive, complicating potential management.
- - Diagnosing heart complications like myocarditis in these patients is challenging, often relying on cardiac imaging rather than biopsies, and this paper explores the issues of accurately diagnosing and treating diseases related to collagen and anti-SRP antibodies.
Article Synopsis
- Age-related macular degeneration (AMD) is a major cause of blindness worldwide, and the use of intravitreal complement inhibitors is a promising treatment strategy that the review evaluates for geographic atrophy (GA) in AMD cases.* -
- The analysis included 18 studies covering 4272 patients, predominantly white females around 78 years old, revealing no significant visual function changes between patients receiving the treatment and control groups.* -
- While complement inhibitors show potential as a therapy for GA in AMD, the analysis suggests a need for personalized patient selection to enhance treatment outcomes.*
: Systemic inflammatory indices have been largely investigated for their potential predictive value in multiple inflammatory, infectious, and oncological diseases; however, their value in colorectal cancer is still a subject of research. This study investigates the dynamics of pre- and postoperative values of NLR, PLR, SII, and MLR in patients with colorectal cancer and their predictive value for early postoperative outcomes. : A 2-year retrospective cohort study was performed on 200 patients operated for colorectal adenocarcinoma.
View Article and Find Full Text PDF