Publications by authors named "A Daryani"
Toxoplasmosis which is caused by T. gondii, is common among humans and animals. T.
View Article and Find Full Text PDFStructural Prediction and Antigenic Analysis of ROP18, MIC4, and SAG1 Proteins to Improve Vaccine Design against Toxoplasma gondii: An In silico Approach.
Infect Disord Drug Targets
September 2024
Background: Toxoplasmosis is a cosmopolitan infectious disease in warm-blooded mammals that poses a serious worldwide threat due to the lack of effective medications and vaccines.
Aims: The purpose of this study was to design a multi-epitope vaccine using several bioinfor-matics approaches against the antigens of Toxoplasma gondii (T. gondii).
Article Synopsis
- Congenital toxoplasmosis in pregnant women is primarily caused by the first-time infection of Toxoplasma gondii, and treatments typically involve antibiotics like spiramycin and clindamycin, each with limitations in efficacy due to poor placental penetration.
- A study investigated the use of chitosan-coated niosomes (Cs-Nio) to enhance the delivery and effectiveness of clindamycin against the VEG strain of T. gondii in a pregnant mouse model.
- Results showed that Cs-Nio-Cli treatment significantly reduced T. gondii cysts in the brain and eyes, improved tissue health, and reduced inflammation and cell death, demonstrating a promising approach to treat congenital toxoplasmosis.
in rodents and shrews in Armenia, Transcaucasia.
Int J Parasitol Parasites Wildl
December 2024
infections in small mammals are important because they serve as source of infection for the felids who excrete environmentally resistant oocysts in their feces. Here, the authors sought evidence for infection in shrews and rodents in Armenia for the first time. DNA was detected in tissues of trapped animals using a specific PCR targeting gene with a non-coding fragment length of 529 bp.
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