Development of a Fully Protective Pandemic Avian Influenza Subunit Vaccine in Insect Pupae.

In this study, we pioneered an alternative technology for manufacturing subunit influenza hemagglutinin (HA)-based vaccines. This innovative method involves harnessing the pupae of the Lepidoptera () as natural biofactories in combination with baculovirus vectors (using CrisBio technology). We engineered recombinant baculoviruses encoding two versions of the HA protein (trimeric or monomeric) derived from a pandemic avian H7N1 virus A strain (A/chicken/Italy/5093/99).

Exploring the Antiviral Potential of Natural Compounds against Influenza: A Combined Computational and Experimental Approach.

The influenza A virus nonstructural protein 1 (NS1), which is crucial for viral replication and immune evasion, has been identified as a significant drug target with substantial potential to contribute to the fight against influenza. The emergence of drug-resistant influenza A virus strains highlights the urgent need for novel therapeutics. This study proposes a combined theoretical criterion for the virtual screening of molecular libraries to identify candidate NS1 inhibitors.

Sensing lead ions in water: a comprehensive review on strategies and sensor materials.

It is well-known fact that elevated lead ions (Pb), the third most toxic among heavy metal ions in aqueous systems, pose a threat to human health and aquatic ecosystems when they exceed permissible limits. Pb is commonly found in industrial waste and fertilizers, contaminating water sources and subsequently entering the human body, causing various adverse health conditions. Unlike being expelled, Pb accumulates within the body, posing potential health risks.

Genetic diversification patterns in swine influenza A virus (H1N2) in vaccinated and nonvaccinated animals.

Influenza A viruses (IAVs) are characterized by having a segmented genome, low proofreading polymerases, and a wide host range. Consequently, IAVs are constantly evolving in nature causing a threat to animal and human health. In 2009 a new human pandemic IAV strain arose in Mexico because of a reassortment between two strains previously circulating in pigs; Eurasian "avian-like" (EA) swine H1N1 and "human-like" H1N2, highlighting the importance of swine as adaptation host of avian to human IAVs.

Machine learning approach for detecting Covid-19 from speech signal using Mel frequency magnitude coefficient.

The Covid-19 pandemic is one of the most significant global health concerns that have emerged in this decade. Intelligent healthcare technology and techniques based on speech signal and artificial intelligence make it feasible to provide a faster and more efficient timely detection of Covid-19. The main objective of our study is to design speech signal-based noninvasive, low-cost, remote diagnosis of Covid-19.