The Ketogenic Diet for Refractory Mental Illness: A Retrospective Analysis of 31 Inpatients.

Background And Hypothesis: The robust evidence base supporting the therapeutic benefit of ketogenic diets in epilepsy and other neurological conditions suggests this same metabolic approach may also benefit psychiatric conditions.

Study Design: In this retrospective analysis of clinical care, 31 adults with severe, persistent mental illness (major depressive disorder, bipolar disorder, and schizoaffective disorder) whose symptoms were poorly controlled despite intensive psychiatric management were admitted to a psychiatric hospital and placed on a ketogenic diet restricted to a maximum of 20 grams of carbohydrate per day as an adjunct to conventional inpatient care. The duration of the intervention ranged from 6 to 248 days.

Asking photons where they have been.

We present surprising experimental evidence regarding the past of photons passing through an interferometer. The information about the positions through which the photons pass in the interferometer is retrieved from modulations of the detected signal at the vibration frequencies of mirrors the photons bounce off. From the analysis we conclude that the past of the photons is not represented by continuous trajectories, although a "common sense" analysis adopted in various welcher weg measurements, delayed-choice which-path experiments, and counterfactual communication demonstrations yields a single trajectory.

Functional cone rescue by RdCVF protein in a dominant model of retinitis pigmentosa.

In retinitis pigmentosa (RP), a majority of causative mutations affect genes solely expressed in rods; however, cone degeneration inevitably follows rod cell loss. Following transplantation and in vitro studies, we demonstrated the role of photoreceptor cell paracrine interactions and identified a Rod-derived Cone Viability Factor (RdCVF), which increases cone survival. In order to establish the clinical relevance of such mechanism, we assessed the functional benefit afforded by the injection of this factor in a frequent type of rhodopsin mutation, the P23H rat.

[ISO 9001-2000 certification for refractive laser treatment].

Purpose: To obtain ISO 9001-2000 certification for laser corneal refractive treatment, never before sought in Europe.

Material And Methods: The consulting firm Veritas led the certification process with the clinic's staff manager. This ISO norm is dedicated to the implementation of a quality management system.

beta-Glycosides of 2,3-Diazido-2,3-dideoxy-D-mannose, a Synthetic Precursor of a Rare Bacterial Cell-Wall Building Unit.

2,3-Diazido-2,3-dideoxy-beta-D-mannopyranoside derivatives were synthesized in order to prepare beta-glycosides of 2,3-diacetamido-2,3-dideoxy-D-mannuronic acid, a rare moiety of bacterial oligosaccharides. A direct glycosyl donor, 4,6-di-O-acetyl-2,3-diazido-2,3-dideoxy-alpha-D-mannopyranosyl bromide, was prepared, and its synthetic capacity was tested in glycosylation reactions. An indirect route was also elaborated: 3-azido-3-deoxy-beta-D-glucopyranosides were converted into beta-D-mannopyranosides.