Publications by authors named "A Damdinsuren"
Objective: To develop and implement a pilot educational program on genetic testing at the Tokai University School of Medicine with a public engagement approach through a local junior-high school outreach program.
Methods: Seven medical students underwent 2 weeks of education and training to act as instructors for a one-day course on genetic testing for local junior-high school students. The one-day course comprised a lecture and an experimental lesson.
Objectives: The aim of this study was to assess the maternal and neonatal outcome in patients with preterm prematurerupture of membranes between 22 to 37 weeks of gestation in comparison to preterm birth patients.
Material And Methods: Group of PPROM patients consisted of 127 women, the control group counted 141 women whodelivered prematurely. The control group was formed by matching patient with the same gestational age at deliveryand neonatal birth weight to every woman from study group.
Internal tandem duplication (ITD) mutations of the FLT3 gene (FLT3-ITD) are well known to correlate with a poor prognosis in acute myeloid leukemia (AML). We previously reported that FLT3-ITD confers resistance to cytosine arabinoside (Ara-C), a key cytotoxic agent in AML treatments. In order to elucidate the detailed molecular mechanisms underlying the Ara-C resistance induced by FLT3-ITD, we performed a microarray gene expression analysis of the human leukemic cell line K562 transduced with FLT3-ITD (K562/FLT3-ITD) and identified RUNX3 as a downstream target of FLT3-ITD.
View Article and Find Full Text PDFObjectives: To evaluate the usefulness of sonography for monitoring the response to glucocorticoid treatment in patients with immunoglobulin G4 (IgG4)-related disease.
Methods: We conducted a retrospective study using sonography in 12 patients with bilateral swollen submandibular glands who had a diagnosis of IgG4-related disease based on an elevated serum IgG4 level (>135 mg/dL) and histopathologic findings between January 2010 and December 2012. Among these patients, 6 were treated with prednisolone, and the other 6 were placed under observation.
Article Synopsis
- - The study investigates the role of leukemic stem cells (LSC) in the progression of acute promyelocytic leukemia (APL), focusing on the PML-RARα fusion protein and its impact on cell development.
- - Researchers created a humanized in vivo APL model by transplanting PML-RARA-transduced CD34(+) human hematopoietic cells into immunodeficient mice, which effectively mimicked human APL characteristics.
- - The findings indicate that common myeloid progenitors (CMP) derived from CD34(+)/CD38(+) cells are critical targets in APL initiation, while the resulting CD34(-) APL cells may have potential for tumor maintenance.