Prognostic factors in Crohn's disease: a systematic review.

Background: The natural history of Crohn's disease is associated with several factors that affect the prognostic of the patients.

Aims: To determine the most prognostic factors in Crohn's disease, based on a systematic review.

Methods: Literature review.

Prothrombin time prolongation in paracetamol poisoning: a relevant marker of hepatic failure?

The association between paracetamol overdose and prolonged prothrombin time due to hepatic failure is well recognized. However, little is known of the possibility that paracetamol overdose can prolong the prothrombin time without overt hepatic failure. The few data from the literature suggest this is either due to a reduction in the functional levels of the vitamin K-dependent clotting factors by elevated doses of paracetamol, or a consequence of the administration of the antidote N-acetylcystein.