Gut microbiota are fundamental for healthy animal function, but the evidence that host function can be predicted from microbiota taxonomy remains equivocal, and natural populations remain understudied compared to laboratory animals. Paired analyses of covariation in microbiota and host parameters are powerful approaches to characterise host-microbiome relationships mechanistically, especially in wild populations of animals that are also lab models, enabling insight into the ecological basis of host function at molecular and cellular levels. The fruitfly is a preeminent model organism, amenable to field investigation by 'omic analyses.
View Article and Find Full Text PDFBackground: Microprocessor knees (MPKs) improve the functional mobility, quality of life, and safety of individuals with a knee disarticulation or above knee amputation and are cost-effective when adjusting for quality-of-life years gained. However, few studies have been conducted on the K2 population, and to this point, the Centers for Medicare and Medicaid Services has not covered MPKs for the K2 population.
Objectives: The aim of this study was to determine the extent to which MPK provision to the K2 population is cost effective at the person and population levels.
Objectives: It is not clear whether the association between younger age at menopause and increased risk of dementia is modified by type of menopause. We examined the association of age at menopause or hysterectomy with dementia risk in three groups of women: those with natural menopause, premenopausal bilateral oophorectomy (surgical menopause) or premenopausal hysterectomy (without bilateral oophorectomy).
Study Design: Individual-level data from 233 802 women in five prospective cohort studies (from four countries) were harmonized and pooled.
Background: Current estimates of dementia and Alzheimer's disease incidence and prevalence are required to understand the health needs of the elderly.
Objective: We used two Australia cohort studies, administrative datasets, and data linkage techniques to estimate dementia rates in Australia.
Methods: The study used Australian Longitudinal Study on Women's Health and the Health in Men Cohort Study.