Publications by authors named "A D firsova"
Targeted spatial transcriptomic methods capture the topology of cell types and states in tissues at single-cell and subcellular resolution by measuring the expression of a predefined set of genes. The selection of an optimal set of probed genes is crucial for capturing the spatial signals present in a tissue. This requires selecting the most informative, yet minimal, set of genes to profile (gene set selection) for which it is possible to build probes (probe design).
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- Hydroelectric dams, like those on the Angara River, create reservoirs that support new aquatic ecosystems, influencing the distribution of microorganisms.
- A study of silica-scaled chrysophytes in South Baikal and Irkutsk Reservoir identified 31 species; however, only 7 were found in South Baikal, while Irkutsk Reservoir hosted a dominant species alongside three others.
- The highest species diversity (23 species) was observed in a shallow bay of Irkutsk Reservoir, likely due to optimal temperature and pH conditions, along with nutrient levels that favored growth.
The complex traditional treatment of inflammation diseases in oral cavity includes the prescription of antibiotic and antiseptic therapy. This systematic review aims to evaluate the effect of photodynamic therapy as a part of management of inflammatory diseases in oral cavity; Methods: The study is presented in accordance with the preferred reporting points for systematic reviews and meta-analyses (PRISMA). This systematic review was conducted using electronic databases such as Medline PubMed, Scopus and the Cochrane Central Register of Controlled Trials.
View Article and Find Full Text PDFSpatially resolved transcriptomics has enabled precise genome-wide mRNA expression profiling within tissue sections. The performance of methods targeting the polyA tails of mRNA relies on the availability of specimens with high RNA quality. Moreover, the high cost of currently available spatial resolved transcriptomics assays requires a careful sample screening process to increase the chance of obtaining high-quality data.
View Article and Find Full Text PDFThe lung contains numerous specialized cell types with distinct roles in tissue function and integrity. To clarify the origins and mechanisms generating cell heterogeneity, we created a comprehensive topographic atlas of early human lung development. Here we report 83 cell states and several spatially resolved developmental trajectories and predict cell interactions within defined tissue niches.
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