Publications by authors named "A D de Sousa Junior"
A pupillary image dataset: 10,000 annotated and 258,790 non-annotated images of patients with glaucoma, diabetes, and subjects influenced by alcohol, coupled with a segmentation performance evaluation.
Comput Biol Med
January 2025
The Pupillary Light Reflex (PLR) is the involuntary movement of the pupil adapting to lighting conditions. The measurement and qualification of this information have a broad impact in different fields. Thanks to technological advancements and algorithms, obtaining accurate and non-invasive records of pupillary movements is now possible, expanding practical applications.
View Article and Find Full Text PDFMinimal Change Disease and Focal Segmental Glomerulosclerosis are associated with good kidney prognosis and Thrombotic Microangiopathy with poor kidney survival in patients with COVID-19-associated nephropathies.
Am J Nephrol
December 2024
Article Synopsis
- * Among 94 patients, most were male and half had a history of hypertension; commonly observed kidney issues included collapsing glomerulopathy (CG), focal segmental glomerulosclerosis (FSGS), and thrombotic microangiopathy (TMA).
- * Results indicated that FSGS and minimal change disease (MCD) were linked to better kidney survival compared to TMA, underscoring differences in kidney complications resulting from COVID-19 within this patient group.
The poor prognosis of colorectal cancer (CRC) is mainly associated with the highly invasive nature, delayed diagnosis, multidrug-resistant cells, tumor recurrence, and metastasis. Targeted therapies offer a promising means to enhance drug accumulation at the tumor site with the aid of cell-targeting ligands. Herein, chitosan-based multifunctional nanoparticles, conjugated with methotrexate (MTX) by covalent bonds, were designed for targeted delivery of 5-fluorouracil (5-FU) to improve CRC therapy.
View Article and Find Full Text PDFArticle Synopsis
- - The study evaluated the effectiveness of atraumatic restorative treatment (ART) for elderly patients needing home dental care, using a cohort of 35 individuals who received 103 restorations.
- - One year post-treatment, ART showed a high success rate (73.8% of restorations remained without replacement), with specific surface types exhibiting better outcomes than others.
- - The findings suggest that ART is an effective and practical option for providing dental care in home settings for the elderly, who often face mobility challenges.
Stratifying clinically relevant risk factors for acute ischemic stroke and cerebrovascular events in chagas disease: A systematic review and meta-Analysis.
Curr Probl Cardiol
December 2024
Article Synopsis
- * After analyzing six studies with 1,229 patients, it was found that reduced left ventricular ejection fraction (LVEF), atrial fibrillation (AF), left ventricular apical aneurysm (LVAA), and pacemaker use significantly elevate the risk of stroke, while anticoagulation therapy appears to reduce the likelihood of having a stroke.
- * The researchers conclude that certain heart-related conditions are linked to higher AIS risk in CD patients, suggesting a need for more randomized studies to develop effective prevention strategies for these individuals.