Divergent Synthesis of Novel 3(5)-Aminoazole-Benzopyrone Hybrids and their Evaluation as α-Glucosidase Inhibitors.

An efficient approach has been developed for the trapping in situ generated benzopyrone-based ortho-quinone methide intermediates by 3- and 5-amino pyrazoles or isoxazoles. In cases of naturally occurring phenolic Mannich bases, hybrid compounds between the azole and flavonoid, namely, coumarin, chromone, isoflavone, and aurone were synthesized in moderate to good yields. It is remarkable that depending on 3- or 5-position of the amino group, the reaction led to the formation of C-4 or 3-NH substituted azole derivatives, respectively.

Effect of Thermal Processing on the Structural and Magnetic Properties of Epitaxial CoFeGe Films.

The structure and magnetic properties of epitaxial Heusler alloy films (CoFeGe) deposited on MgO (100) substrates were investigated. Films of 60 nm thickness were prepared by magnetron co-sputtering at different substrate temperatures (T), and those deposited at room temperature were later annealed at various temperatures (T). X-ray diffraction confirmed (001) [110] CoFeGe || (001) [100] MgO epitaxial growth.

Slovenia's Food-Based Dietary Guidelines 2024: Eating for Health and the Planet.

The dietary guidelines of Slovenia, '12 Steps to Healthy Eating', were first published in 2000 and revised in 2011. The 'Food Guide Pyramid' was initially published in 2000 and subsequently revised in 2015. 'The Healthy Plate' was first introduced in 2007.

Endoscopic light-guided choledochoduodenostomy in the treatment of the distal common bile duct obstruction.

Objective: Aim: Experimental justification for creation of bile offtake into the duodenum with minimally invasive methods in cases of obstruction of the distal part of common bile duct and failure of transpapillary interventions and studying the first results of such intervention application.

Patients And Methods: Materials and Methods: The anatomical relationships between the duodenum and the common bile duct in its distal parts starting from its retroduodenal part to the sphincter of Oddi were studied. The possibility of transillumination of the walls of the common bile duct and the duodenum by a light source introduced into the lumen of the common bile duct is determined.

Trapping of thermally generated - and -quinone methides by imidazoles and pyrazoles: a simple route to green synthesis of benzopyrone-azole hybrids and their evaluation as α-glucosidase inhibitors.

An efficient green approach for the trapping of generated -and -quinone methide intermediates by imidazoles and pyrazoles has been developed. A wide range of quinone methide precursors based on simple phenols are compatible with the experimental protocol under mild thermal conditions. This methodology was demonstrated to be suitable for the synthesis of methylene-linked benzopyrone-azole hybrids using naturally occurring coumarin and chromone Mannich bases.