Loss of GTF2I promotes neuronal apoptosis and synaptic reduction in human cellular models of neurodevelopment.

Individuals with Williams syndrome (WS), a neurodevelopmental disorder caused by hemizygous loss of 26-28 genes at 7q11.23, characteristically portray a hypersocial phenotype. Copy-number variations and mutations in one of these genes, GTF2I, are associated with altered sociality and are proposed to underlie hypersociality in WS.

Principles of weakly ordered domains in intermetallics: the cooperative effects of atomic packing and electronics in FeAl.

Many complex intermetallic structures feature a curious juxtaposition of domains with strict 3D periodicity and regions of much weaker order or incommensurability. This article explores the basic principles leading to such arrangements through an investigation of the weakly ordered channels of FeAl. It starts by experimentally confirming the earlier crystallographic model of the high-temperature form, in which nearly continuous columns of electron density corresponding to disordered Al atoms emerge.

Deciphering composition and connectivity of a natural product with the assistance of MS and 2D NMR.

A complementary application of three analytical techniques, viz. multidimensional nuclear magnetic resonance spectroscopy (NMR), mass spectrometry (MS), and single-crystal X-ray diffractometry was required to identify and refine two natural products isolated from Millettia versicolor and solvent of crystallization. The two compounds, namely 3-(2H-1,3-benzodioxol-5-yl)-6-methoxy-8,8-dimethyl-4H,8H-pyrano[2,3-h]chromen-4-one, or durmillone, (I), and (2E)-1-(4-{[(2E)-3,7-dimethylocta-2,6-dien-1-yl]oxy}-2-hydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one, (II), could not be separated by routine column chromatography and cocrystallized in a 2:1 ratio with 0.

Crystal structure of {()--[(benzo[]quinolin-2-yl)meth-yl]--[(benzo[]quinolin-2-yl)methyl-idene]-1,1'-binaphthyl-2,2'-di-amine-κ,','','''}(trifluoromethane-sulfonato-κ)zinc(II)} trifluoromethane-sulfonate di-chloro-methane 1.5-solvate.

The zinc(II) atom in the title compound, [Zn(CHN)(CFSO)](CFSO)·1.5CHCl, adopts a distorted five-coordinate square-pyramidal geometry. It is coordinated by one tri-fluoro-methane-sulfonate ligand and four N atoms of the -[(benzo[]quinolin-2-yl)meth-yl]--[(benzo[]quinolin-2-yl)methyl-idene]-1,1'-binaphthyl-2,2'-di-amine ligand.

Crystal structure of ({(1,2)-,'-bis-[(quino-lin-2-yl)methyl]cyclo-hexane-1,2-di-amine}-chlorido-iron(III))-μ-oxido-[tri-chlorido-ferrate(III)] chloro-form monosolvate.

The first Fe atom in the solvated title compound, [FeClO(CHN)]·CHCl, adopts a distorted six-coordinate octa-hedral geometry. It is coordinated by one chloride ligand, four N atoms from the (1,2)-,'-bis-[(quinolin-2-yl)methyl]cyclo-hexane-1,2-di-amine ligand, and a bridging oxido ligand attached to the second Fe atom, which is also bonded to three chloride ions. A very weak intra-molecular N-H⋯Cl hydrogen bond occurs.