Diverse Interactions of Sterols with Amyloid Precursor Protein Transmembrane Domain Can Shift Distribution Between Alternative Amyloid-β Production Cascades in Manner Dependent on Local Lipid Environment.

Alzheimer's disease (AD) pathogenesis is correlated with the membrane content of various lipid species, including cholesterol, whose interactions with amyloid precursor protein (APP) have been extensively explored. Amyloid-β peptides triggering AD are products of APP cleavage by secretases, which differ depending on the APP and secretase location relative to ordered or disordered membrane microdomains. We used high-resolution NMR to probe the interactions of the cholesterol analog with APP transmembrane domain in two membrane-mimicking systems resembling ordered or perturbed lipid environments (bicelles/micelles).

Thermal comfort perception among park users in Prague, Central Europe on hot summer days-A comparison of thermal indices.

The assessment of human perception of the thermal environment is becoming highly relevant in the context of global climate change and its impact on public health. In this study, we aimed to evaluate the suitability of the use of four frequently used thermal comfort indices (thermal indices)-Wet Bulb Global Temperature (WGBT), Heat Index (HI), Physiologically Equivalent Temperature (PET), and Universal Thermal Climate Index (UTCI)-to assess human thermal comfort perception in three large urban parks in Central Europe, using Prague, the capital of the Czech Republic, as a case study. We investigated the relationship between the four indices and the thermal perception of park visitors, while taking into account the effect of the sex, age, and activity of the respondents and the week-time and daytime of their visit (assessed parameters).

Large Scale in vivo Acquisition, Segmentation and 3D Reconstruction of Cortical Vasculature using Doppler Ultrasound Imaging.

The brain is composed of a dense and ramified vascular network of arteries, veins and capillaries of various sizes. One way to assess the risk of cerebrovascular pathologies is to use computational models to predict the physiological effects of reduced blood supply and correlate these responses with observations of brain damage. Therefore, it is crucial to establish a detailed 3D organization of the brain vasculature, which could be used to develop more accurate in silico models.

Integrating Practice-Changing Studies in Gynaecologic Oncology Through Clinical Illustrations.

Advances in gynaecologic oncology research lead to continuous updates in clinical guidelines. However, undergraduate medical education often lacks in-depth coverage of recent developments, limiting students' preparedness for evidence-based management of gynaecological cancers. This study aimed to bridge the educational gap by integrating case-based analyses of practice-changing studies into the undergraduate obstetrics and gynaecology course.

Rapid climate action is needed: comparing heat vs. COVID-19-related mortality.

The impacts of climate change on human health are often underestimated or perceived to be in a distant future. Here, we present the projected impacts of climate change in the context of COVID-19, a recent human health catastrophe. We compared projected heat mortality with COVID-19 deaths in 38 cities worldwide and found that in half of these cities, heat-related deaths could exceed annual COVID-19 deaths in less than ten years (at + 3.