Publications by authors named "A D Thames"
Article Synopsis
- - The 14th International Workshop on HIV and Aging, held on October 26-27, 2023, focused on improving health span for people living with HIV (PWH) by exploring issues related to aging and comorbid conditions.
- - Key topics included the biology and treatment of sarcopenia, long-acting antiretroviral therapy (ART), and complications related to the central nervous system, along with mental health and social factors.
- - Presentations emphasized the need for prioritizing mental health care, addressing loneliness, and conducting research on resilience among PWH to tackle ongoing challenges.
Article Synopsis
- * Barriers to participation in studies include medical mistrust, limited access, and strict inclusion criteria, which are often overlooked in research design.
- * Community-engaged research (CER) methods, guided by frameworks like Community-Based Participatory Research (CBPR), aim to address these challenges and were utilized in the Black Women Inflammation and Tau Study (BWITS) to identify relevant biopsychosocial risk factors for ADRD in Black women.
Deficits in memory performance have been linked to a wide range of neurological and neuropsychiatric conditions. While many studies have assessed the memory impacts of individual conditions, this study considers a broader perspective by evaluating how memory recall is differentially associated with nine common neuropsychiatric conditions using data drawn from 55 international studies, aggregating 15,883 unique participants aged 15-90. The effects of dementia, mild cognitive impairment, Parkinson's disease, traumatic brain injury, stroke, depression, attention-deficit/hyperactivity disorder (ADHD), schizophrenia, and bipolar disorder on immediate, short-, and long-delay verbal learning and memory (VLM) scores were estimated relative to matched healthy individuals.
View Article and Find Full Text PDF-linked glycosylation plays a key role in the efficacy of many therapeutic proteins. One limitation to the bacterial glycoengineering of human -linked glycans is the difficulty of installing a single -acetylglucosamine (GlcNAc), the reducing end sugar of many human-type glycans, onto asparagine in a single step (-GlcNAcylation). Here, we develop an method for -GlcNAcylating proteins using the oligosaccharyltransferase PglB from .
View Article and Find Full Text PDFThe hydroxyl radical (OH) fuels atmospheric chemical cycling as the main sink for methane and a driver of the formation and loss of many air pollutants, but direct OH observations are sparse. We develop and evaluate an observation-based proxy for short-term, spatial variations in OH (Proxy) in the remote marine troposphere using comprehensive measurements from the NASA Atmospheric Tomography (ATom) airborne campaign. Proxy is a reduced form of the OH steady-state equation representing the dominant OH production and loss pathways in the remote marine troposphere, according to box model simulations of OH constrained with ATom observations.
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