Preclinical evaluation of DC-CIK cells as potentially effective immunotherapy model for the treatment of glioblastoma.

Despite the favorable effects of immunotherapies in multiple types of cancers, its complete success in CNS malignancies remains challenging. Recently, a successful clinical trial of cytokine-induced killer (CIK) cell immunotherapy in patients with glioblastoma (GBM) has opened a new avenue for adoptive cellular immunotherapies in CNS malignancies. Prompt from these findings, herein, we investigated whether dendritic cells (DC) in combination with cytokine-induced killer cells (DC-CIK) could also provide an alternative and more effective way to improve the efficacy of GBM treatment.

Disentangling Sources of Momentum Fluctuations in Xe+Xe and Pb+Pb Collisions with the ATLAS Detector.

High-energy nuclear collisions create a quark-gluon plasma, whose initial condition and subsequent expansion vary from event to event, impacting the distribution of the eventwise average transverse momentum [P([p_{T}])]. Disentangling the contributions from fluctuations in the nuclear overlap size (geometrical component) and other sources at a fixed size (intrinsic component) remains a challenge. This problem is addressed by measuring the mean, variance, and skewness of P([p_{T}]) in ^{208}Pb+^{208}Pb and ^{129}Xe+^{129}Xe collisions at sqrt[s_{NN}]=5.

Aging in a weighted ensemble of excitable and self-oscillatory neurons: The role of pairwise and higher-order interactions.

We investigate the aging transition in networks of excitable and self-oscillatory units as the fraction of inherently excitable units increases. Two network topologies are considered: a scale-free network with weighted pairwise interactions and a two-dimensional simplicial complex with weighted scale-free pairwise and triadic interactions. Without triadic interactions, the aging transition from collective oscillations to oscillation death (inhomogeneous stationary states) can occur either suddenly or through an intermediate state of partial oscillation.

Basic Science and Pathogenesis.

Background: Progressive supranuclear palsy (PSP) is the most common primary tauopathy, with a constellation of pathological features including 4R-tau positive neurofibrillary tangles and tufted astrocytes. Most PSP cases are sporadic and associated with common structural variation in the 17q21.31 MAPT locus as well as other loci, including EIF2AK3 which is critical for the integrated stress response (ISR).

Clinical Manifestations.

Background: Alzheimer's disease (AD) pathology (e.g., beta-amyloid plaques, tau neurofibrillary tangles) accumulates before the emergence of cognitive deficits that lead to a diagnosis of mild cognitive impairment (MCI) or dementia.