Ventilation distribution during spontaneous breathing trials predicts liberation from mechanical ventilation: the VISION study.

Background: Predicting complete liberation from mechanical ventilation (MV) is still challenging. Electrical impedance tomography (EIT) offers a non-invasive measure of regional ventilation distribution and could bring additional information.

Research Question: Whether the display of regional ventilation distribution during a Spontaneous Breathing Trial (SBT) could help at predicting early and successful liberation from MV.

Lifespan in rodents with MYT1L heterozygous mutation.

MYT1L syndrome is a newly recognized disorder characterized by intellectual disability, speech and motor delay, neuroendocrine disruptions, ADHD, and autism. In order to study this gene and its association with these phenotypes, our lab recently created a heterozygous mutant mouse inspired by a clinically relevant mutation. This model recapitulates several of the physical and neurologic abnormalities seen in humans with MYT1L syndrome, such as weight gain, microcephaly, and behavioral disruptions.

Presence of multidrug-resistant bacteria on ready-to-use laryngoscope blades and handles: a cross-sectional study.

Background: The presence of microorganisms in laryngoscopes emphasizes the risk to patient safety during orotracheal intubations.

Methods: Cross-sectional study was carried out in university hospital in the inpatient, emergency, intensive care and surgical center sectors. Microorganisms were recovered from the blades using a filter membrane and from the handles using swab.

Pathogen-Specific Electrochemical Real-Time LAMP Detection Using Universal Solid-Phase Probes on Carbon Electrodes.

Epidemic infections and spreading antibiotic resistance require diagnostic tests that can be rapidly adopted. To reduce the usually time-consuming adaptation of molecular diagnostic tests to changing targets, we propose the novel approach of a repurposable sensing electrode functionalization with a universal, target-independent oligonucleotide probe. In the liquid phase covering the electrode, the target sequence is amplified by MD LAMP (mediator-displacement loop-mediated isothermal amplification) releasing a generic methylene blue-labeled mediator, which specifically hybridizes to the solid-phase probe.

Enhancing Antifungal Drug Discovery Through Co-Culture with Antarctic Strain CBMAI 1855.

Fungal infections pose a growing public health threat, creating an urgent clinical need for new antifungals. Natural products (NPs) from organisms in extreme environments are a promising source for novel drugs. CBMAI 1855 exhibited significant potential in this regard.