Intracerebroventricular anaerobic dopamine in Parkinson's disease with L-dopa-related complications: a phase 1/2 randomized-controlled trial.

Continuous compensation for cerebral dopamine deficiency represents an ideal treatment for Parkinson's disease. Dopamine does not cross the digestive and blood-brain barriers and is rapidly oxidized. The new concept is the intracerebroventricular administration of anaerobic dopamine (A-dopamine) using an abdominal pump connected to a subcutaneous catheter implanted in the third ventricle, near the striatum.

Elucidating Protein Structures in the Gas Phase: Traversing Configuration Space with Biasing Methods.

Achieving accurate characterization of protein structures in the gas phase continues to be a formidable challenge. To tackle this issue, the present study employs Molecular Dynamics (MD) simulations in tandem with enhanced sampling techniques (methods designed to efficiently explore protein conformations). The objective is to identify suitable structures of proteins by contrasting their calculated Collision Cross-Section (CCS) with those observed experimentally.

[Scientific rationale for Clinical Practice Guidelines (part 2): what is the effectiveness of retention devices?].

Introduction: Retention is the set of means, processes or devices that contribute to maintaining the teeth in the position and the arches in the shape given by the orthodontic treatment. The main objective is to propose Clinical Practice Guidelines (CPG) on orthodontic retention by answering four main questions. This article provides the first part of the answer to the second question: How effective are the retention devices?

Materials And Methods: A literature review was carried out after a bibliographic search using keywords in bibliographic databases and in international organizations websites.

[Scientific rationale for Clinical Practice Guidelines (part 1): what are the factors that determine the choice of retention?].

Introduction: Retention is the set of means, processes or devices that contribute to maintaining the teeth in the position and the arches in the shape given by the orthodontic treatment. The main objective is to propose Clinical Practice Guidelines (CPG) on orthodontic retention by answering 4 main questions. This article provides the answer to the first question: What are the factors that determine whether or not to use a retainer?

Material And Methods: A literature review was carried out after a bibliographic search using keywords in bibliographic databases and in international organizations websites.