Publications by authors named "A D R Nina Junior"
Minimal Change Disease and Focal Segmental Glomerulosclerosis are associated with good kidney prognosis and Thrombotic Microangiopathy with poor kidney survival in patients with COVID-19-associated nephropathies.
Am J Nephrol
December 2024
Article Synopsis
- * Among 94 patients, most were male and half had a history of hypertension; commonly observed kidney issues included collapsing glomerulopathy (CG), focal segmental glomerulosclerosis (FSGS), and thrombotic microangiopathy (TMA).
- * Results indicated that FSGS and minimal change disease (MCD) were linked to better kidney survival compared to TMA, underscoring differences in kidney complications resulting from COVID-19 within this patient group.
The poor prognosis of colorectal cancer (CRC) is mainly associated with the highly invasive nature, delayed diagnosis, multidrug-resistant cells, tumor recurrence, and metastasis. Targeted therapies offer a promising means to enhance drug accumulation at the tumor site with the aid of cell-targeting ligands. Herein, chitosan-based multifunctional nanoparticles, conjugated with methotrexate (MTX) by covalent bonds, were designed for targeted delivery of 5-fluorouracil (5-FU) to improve CRC therapy.
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- - The study evaluated the effectiveness of atraumatic restorative treatment (ART) for elderly patients needing home dental care, using a cohort of 35 individuals who received 103 restorations.
- - One year post-treatment, ART showed a high success rate (73.8% of restorations remained without replacement), with specific surface types exhibiting better outcomes than others.
- - The findings suggest that ART is an effective and practical option for providing dental care in home settings for the elderly, who often face mobility challenges.
Stratifying clinically relevant risk factors for acute ischemic stroke and cerebrovascular events in chagas disease: A systematic review and meta-Analysis.
Curr Probl Cardiol
December 2024
Article Synopsis
- * After analyzing six studies with 1,229 patients, it was found that reduced left ventricular ejection fraction (LVEF), atrial fibrillation (AF), left ventricular apical aneurysm (LVAA), and pacemaker use significantly elevate the risk of stroke, while anticoagulation therapy appears to reduce the likelihood of having a stroke.
- * The researchers conclude that certain heart-related conditions are linked to higher AIS risk in CD patients, suggesting a need for more randomized studies to develop effective prevention strategies for these individuals.
Association between low-density lipoprotein cholesterol levels and all-cause mortality in patients with coronary artery disease: a real-world analysis using data from an international network.
Sci Rep
November 2024
The current cholesterol guidelines recommend maintaining low levels of low-density lipoprotein cholesterol (LDL-C) in patients with coronary artery disease (CAD). However, recent studies have suggested that both very low and very high LDL-C levels may be associated with increased mortality in the general population. We utilized data from TriNetX, a global health research network, to investigate the association between LDL-C levels and all-cause mortality in patients with CAD.
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