Publications by authors named "A D Perlmutter"
Unlabelled: Age-related alterations in immune function are believed to increase risk for a host of age-related diseases leading to premature death and disability. Programming of the immune system by diet, lifestyle, and environmental factors occurs across the lifespan and influences both makeup and function of the immune system, including immunometabolism. This programming is believed to act in large part through epigenetic modification.
View Article and Find Full Text PDFArticle Synopsis
- Previous studies on the impact of nicotine vaping on later substance use (like cannabis and cocaine) faced limitations due to short follow-up periods and inadequate controls for confounding variables.
- This research aimed to fill those gaps using a national dataset from 2013 to 2019, focusing on adolescents transitioning to adulthood and exploring the link between vaping and the initiation of other drugs.
- The findings indicated that lower odds of nicotine vaping were associated with significantly reduced risks of starting cannabis and other substances, suggesting that strategies to reduce vaping prevalence could help prevent early substance use among young people.
Introduction: The benefits and risks of HMG-CoA reductase inhibitor (statin) drugs in survivors of intracerebral hemorrhage (ICH) are unclear. Observational studies suggest an association between statin use and increased risk of lobar ICH, particularly in patients with apolipoprotein-E (APOE) ε2 and ε4 genotypes. There are no randomized controlled trials (RCTs) addressing the effects of statins after ICH leading to uncertainty as to whether statins should be used in patients with lobar ICH who are at high risk for ICH recurrence.
View Article and Find Full Text PDFRecessions, poverty, and unemployment have been associated with opioid use. However, these measures of financial hardship may be imprecise, limiting our ability to understand this relationship. We tested associations between relative deprivation and non-medical prescription opioid use (NMPOU) and heroin use among working-age adults (ages 18-64) during the Great Recession.
View Article and Find Full Text PDFThere is an integral research gap regarding whether there is a relationship between pain levels and low physical activity among older women. This is a secondary analysis of a longitudinal cohort study, the Women's Health and Aging Study (WHAS) II. Our analyses included 436 community-dwelling women between the ages of 70 and 79, who were followed for 10.
View Article and Find Full Text PDF