Publications by authors named "A D Ottolenghi"
Stem cells are the foundation for cell therapy due to their ability to self-renew, differentiate into other cell types, and persist throughout the life of an organism. Stem cell isolation and transplantation have not yet been established in Hexacorallia, a cnidarian subclass containing stony corals and sea anemones. Here, we demonstrate that candidate stem cells in the hexacorallian Nematostella vectensis can be transplanted into adult animals.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates how different SARS-CoV-2 variants, particularly Omicron, respond to vaccine-induced antibodies and their infectivity levels compared to earlier strains like Delta and hCoV-19.
- - Findings reveal that Omicron variants BA.1 and BA.2 show higher infectivity and reduced sensitivity to neutralizing antibodies from a third dose of the Pfizer-BNT162b2 vaccine, while certain mutations in the spike protein affect cell fusion capabilities but not neutralization efficiency.
- - The research highlights that while mutations in the spike protein influence viral fusion and syncytia formation, the overall response to the third vaccine dose indicates significant protection against severe outcomes.
Biological effects of radioactive particles can be experimentally investigated in vitro as a function of particle concentration, specific activity and exposure time. However, a careful dosimetric analysis is needed to elucidate the role of radiation emitted by radioactive products in inducing cyto- and geno-toxicity: the quantification of radiation dose is essential to eventually inform dose-risk correlations. This is even more fundamental when radioactive particles are short-range emitters and when they have a chemical speciation that might further concur to the heterogeneity of energy deposition at the cellular and sub-cellular level.
View Article and Find Full Text PDFDuring melanoma metastasis, tumor cells originating in the skin migrate via lymphatic vessels to the sentinel lymph node (sLN). This process facilitates tumor cell spread across the body. Here, we characterized the innate inflammatory response to melanoma in the metastatic microenvironment of the sLN.
View Article and Find Full Text PDFObjectives: Flat shaped glucose curves (FC) during oral glucose tolerance test (OGTT) in pregnant women (PW) are a not uncommon finding. We aimed to define the FC incidence in a large PW cohort and to describe the status of insulin and C-peptide secretion in women with FC when compared with a well-matched control group.
Methods: 1050 PW performing OGTT for gestational diabetes screening were enrolled.