Niger Postgrad Med J
July 2024
Background: The potential of stem bark as a safe antimalarial agent, and the identification of its antimalarial constituents was explored.
Materials And Methods: The air-dried stem bark was extracted with 70% ethanol, filtered and concentrated to obtain the extract (). The extract was successively partitioned to give -hexane (), dichloromethane (), ethyl acetate () -butanol () and aqueous () fractions respectively after determining the acute toxicity using Lorke's method.
Background: Mitochondrial reactive oxygen species (ROS) generation and defective oxidative phosphorylation (OXPHOS) have been proposed as possible mechanisms underlying the development of nucleoside reverse transcriptase inhibitors (NRTIs)-induced mitochondrial toxicities. Available options in managing these complications have, so far, produced controversial results, thus necessitating further research into newer agents with promise. Antioxidant and free-radical scavenging effects of naringin, a plant-derived flavonoid, have previously been demonstrated.
View Article and Find Full Text PDFIntroduction. Proper implementation of prevention of mother-to-child transmission (PMTCT) services requires adequate knowledge and appropriate attitudes and practices on the part of the health care providers especially in rural areas where access to health care delivery is very limited in Oyo State. Materials and Methods.
View Article and Find Full Text PDFJ Immunoassay Immunochem
October 2016