Publications by authors named "A D McCulloch"
In this study we examined the activation of the non-canonical NFκB signalling pathway in endothelial cells. In HUVECs, LIGHT stimulated a delayed induction of serine 866/870 p100 phosphorylation linked to p52 NFκB formation. Surprisingly, the canonical ligand, IL-1β, stimulated a rapid phosphorylation or p100 which was not associated with p52 formation.
View Article and Find Full Text PDFObjective: Exercise plays a crucial role in maintaining and improving human health. However, the precise molecular mechanisms that govern the body's response to exercise or/compared to periods of inactivity remain elusive. Current evidence appears to suggest that exercise exerts a seemingly dual influence on macrophage polarization states, inducing both pro-immune response M1 activation and cell-repair-focused M2 activation.
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- Patients with dyssynchronous heart failure (DHF) experience uneven heart muscle work due to conduction problems, but cardiac resynchronization therapy (CRT) can improve this synchrony, leading to better health outcomes and quality of life.
- Researchers used advanced computational models to analyze heart function in eight patients with heart failure and left bundle branch block (LBBB) before and after CRT, finding that the therapy enhanced overall myocardial work efficiency.
- The study revealed that the most significant reverse remodeling—improvement of heart structure—occurred in patients who initially had the greatest disparity in regional heart work, with effective CRT linked to increased function in specific areas of the heart rather than a reduction in overall work unevenness.
Article Synopsis
- There is a big mental health problem for kids and teens in the UK, and many of them wait until they are in crisis before getting help.
- Young people feel there isn't enough support available before they get really upset, and police are getting more calls about mental health issues among youth.
- A new study is being done to improve how the police and mental health services work together to help young people in crisis, but there are still not enough resources for proper support.
We present the NetSci program-an open-source scientific software package designed for estimating mutual information (MI) between data sets using GPU acceleration and a k-nearest-neighbor algorithm. This approach significantly enhances calculation speed, achieving improvements of several orders of magnitude over traditional CPU-based methods, with data set size limits dictated only by available hardware. To validate NetSci, we accurately compute MI for an analytically verifiable two-dimensional Gaussian distribution and replicate the generalized correlation (GC) analysis previously conducted on the B1 domain of protein G.
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