Hypoxia-inducible factor 2 regulates alveolar regeneration after repetitive injury in three-dimensional cellular and in vivo models.

Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease in which repetitive epithelial injury and incomplete alveolar repair result in accumulation of profibrotic intermediate/transitional "aberrant" epithelial cell states. The mechanisms leading to the emergence and persistence of aberrant epithelial populations in the distal lung remain incompletely understood. By interrogating single-cell RNA sequencing (scRNA-seq) data from patients with IPF and a mouse model of repeated lung epithelial injury, we identified persistent activation of hypoxia-inducible factor (HIF) signaling in these aberrant epithelial cells.

Development and evaluation of an ovarian hormone profile classification tool for female athletes: step one of a two-step process to determine ovarian hormone profiles.

Objective: This study aimed to develop a reliable, comprehensive and fit-for-purpose tool for classifying ovarian hormone profiles (OHPs) (step one of a two-step process) in postmenarcheal to perimenopausal female athletes.

Methods: The OHP classification tool was designed by a team of sport scientists, practitioners and medics and is intended for use by sport practitioners. It incorporates self-reported data and guides subsequent verification methods.

Effects of Prematch Travel and Training on Physical and Technical Performance in International Football Matches.

Purpose: This study examined the relationship of prematch travel and in-camp training on ensuing physical and technical match performance of footballers (soccer) competing for a national team.

Methods: Match running and technical performance data were obtained from 68 national-team footballers competing in international matches (N = 108). Match performance data were aligned with the confirmed travel durations, time-zone change, travel direction, and time between arrival and kickoff for the travel to the match.

Illness, the overlooked research topic for time-loss in women's football - a scoping review.

The best medical care for female football athletes should be evidence-based, and patient- and context-specific. A 2019 scoping review identified key knowledge gaps relating to the health of female footballers. Since then, research in women's football has been intensifying.