Publications by authors named "A D Marie"
RP-HPLC technique was developed and optimized for simultaneous identification and estimation of nirmatrelvir (NIR) and ritonavir (RIT) in their new copackaged tablet. Stability of nirmatrelvir (NIR) was studied after exposure to different five stress conditions; alkali, acid, heat, photo and oxidation degradation. The chromatographic separation was achieved using VDSpher PUR 100 ODS (4.
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- - The study presents a new method for separating extracellular vesicles (EVs) from plasma, focusing on their surface charges to improve the purity of EVs and reduce contamination by free plasma proteins.
- - This charge-based fractionation technique was optimized through various analyses, including proteomics and electron microscopy, ensuring the effective isolation of EVs from healthy donors.
- - The method was tested on clinical prostate cancer samples, showing promise for enhancing EV-based diagnostics and research, while also being user-friendly and accessible without specialized equipment.
This study represents a comparison among the performances of four multivariate procedures: partial least square (PLS) and artificial neural networks (ANN) in addition to support vector regression (SVR) and extreme gradient boosting (XG Boost) algorithm for the determination of the anti-diabetic mixture of pioglitazone (PIO), alogliptin (ALG) and glimepiride (GLM) in pharmaceutical formulations with aid of UV spectrometry. Key wavelengths were selected using knowledge-based variable selection and various preprocessing methods (e.g.
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