Publications by authors named "A D Makatsariya"
Cerebral vein thrombosis: management tactics with a focus on pregnancy, the use of hormone therapy and assisted reproductive technologies.
J Matern Fetal Neonatal Med
December 2025
Cerebral vein thrombosis is a rare, life-threatening condition that has now become more commonly diagnosed due to advancements in imaging techniques. Our purpose is to improve understanding of pathogenesis, diagnosis and pregnancy and IVF management in patients with a history of cerebral thrombosis. We present an overview of the modern tactics of anticoagulant therapy for cerebral thrombosis with a focus on pregnancy, the use of hormone therapy, and assisted reproductive technologies.
View Article and Find Full Text PDFBackground: In young women with venous thromboembolism (VTE) related to weak transient risk factors, it remains unknown whether stress levels and intimate partner violence (IPV) are associated with recurrence. The VTE-WEAK study aims to investigate the association between perceived stress and IPV with a recurrence of VTE in women with a first episode of VTE due to combined oral contraceptives, pregnancy-puerperium, minor trauma/fracture, brief surgery, infection or brief immobility, and not using antithrombotic prophylaxis.
Material And Methods: We performed a multicenter, international, observational, retrospective study on women referred for thrombophilia screening who were subsequently monitored.
Artificial intelligence (AI) is significantly transforming surgery by enhancing precision, decision-making, and patient outcomes. This bibliometric analysis examines AI's impact on surgery, highlighting research trends, key contributors, and evolving themes from 1998 to 2024. Utilizing data from the Web of Science Core Collection and analyzed through the Bibliometrix tool, the study reviews publication trends, author impact, institutional contributions, country-specific research activities, and keyword frequency.
View Article and Find Full Text PDFArticle Synopsis
- Recent developments have improved our understanding of the molecular processes that lead to thrombus formation, particularly regarding deep vein thrombosis (DVT), which can be triggered by various factors like trauma, immobility, or genetic issues.
- About half of DVT cases are unprovoked, involving mechanisms such as venous stasis and hypoxia, raising the importance of immunothrombosis, especially during conditions like COVID-19 that exacerbate inflammation and promote microthrombi formation.
- Research involving animal models and clinical studies has revealed the intricate relationship between immune cells, blood components, and various factors influencing coagulation, providing a deeper insight into the causes of hypercoagulability and venous thromboembolism.
Article Synopsis
- - Thrombotic microangiopathy (TMA) is a group of disorders where small blood vessel clotting causes organ damage, including conditions like thrombotic thrombocytopenic purpura (TTP) and hemolytic-uremic syndrome (HUS), each with unique causes and impacts on health.
- - In TMA, inflammation leads to endothelial damage and activates platelet and coagulation processes, often linked to low ADAMTS13 enzyme levels, particularly in cancer patients undergoing chemotherapy, which raises thrombotic risk by increasing the VWF/ADAMTS13 ratio.
- - Treatment focuses on diagnosing the specific cause and may include therapies to inhibit complement activation, supportive care, and plasmapheresis