Publications by authors named "A D Litonjua"
Article Synopsis
- The Vitamin D Antenatal Asthma Reduction Trial (VDAART) studied children from 6 months to 8 years and found links between specific gene variants and children's body mass index.
- These associations also connected microbiome characteristics tied to obesity with important lipids and amino acids.
- The findings suggest that genetic factors play a role in influencing the microbiome during development and highlight potential biomarkers for childhood obesity and related health issues like insulin resistance and type 2 diabetes.
Background: MicroRNAs (miRNAs) are involved in the biological regulation of asthma and allergies.
Objective: We sought to investigate the association between cord blood miRNAs and the development of allergic rhinitis and early childhood asthma.
Methods: miRNAs were sequenced from cord blood of subjects participating in the Vitamin D Antenatal Asthma Reduction Trial.
Comparison of Race-neutral Versus Race-specific Spirometry Equations for Evaluation of Child Asthma.
Am J Respir Crit Care Med
December 2024
Rationale: Race-based estimates of pulmonary function in children could influence the evaluation of asthma in children from racial and ethnic minoritized backgrounds.
Objectives: To determine if race-neutral (GLI-Global) versus race-specific (GLI-Race-Specific) reference equations differentially impact spirometry evaluation of childhood asthma.
Methods: The analysis included 8,719 children aged 5 to <12 years from 27 cohorts across the United States grouped by parent-reported race and ethnicity.
Background: The immunometabolic mechanisms underlying variable responses to oral immunotherapy (OIT) in patients with IgE-mediated food allergy are unknown.
Objective: To identify novel pathways associated with tolerance in food allergy, we used metabolomic profiling to find pathways important for food allergy in multiethnic cohorts and responses to OIT.
Methods: Untargeted plasma metabolomics data were generated from the VDAART healthy infant cohort (N = 384), a Costa Rican cohort of children with asthma (N = 1040), and a peanut OIT trial (N = 20) evaluating sustained unresponsiveness (SU, protection that lasts after therapy) versus transient desensitization (TD, protection that ends immediately afterward).
Article Synopsis
- Scientists are trying to understand how certain factors might affect the health of mothers and babies, especially when it comes to birth weight.
- They studied data from over 28,000 mother-baby pairs to see how being exposed to certain environmental factors could impact birth weight and the chances of low birth weight.
- They found that small changes in exposure have a bigger effect on vulnerable groups, showing that these groups face more health challenges than others.