Publications by authors named "A D Lein"
Article Synopsis
- Adenotonsillar hypertrophy is a leading cause of obstructive sleep apnea in children, and there is limited understanding of how clinical symptoms relate to the severity of the condition when adenoid size is not measurable.
- The study aimed to evaluate the relationship between patient characteristics, adenoid size, and clinical symptoms with obstructive sleep apnea severity in children scheduled for adenoidectomy.
- An analysis of 81 pediatric patients showed significant correlations between clinical symptom scores, adenoid-choanal ratios, and apnea-hypopnea index scores, indicating that larger adenoid size and worse symptoms are linked to more severe obstructive sleep apnea across different age groups.
A MAUDE database analysis on the new generation of active bone conduction hearing implants.
Laryngoscope Investig Otolaryngol
October 2024
Objective: To analyze medical device reports (MDR) submitted to the Food and Drug Administration's (FDA) Manufacturer and User Device Facility Experience (MAUDE) database to identify adverse events (AEs) in patients implanted with novel active bone conduction hearing implants (BCIs).
Methods: We conducted a search of the FDA MAUDE database on the newest generation of BCIs. Data were collected concerning device malfunctions, patient injuries, factors triggering these incidents, and the subsequent actions taken.
: The anti-neoplastic activity of metformin is a subject of current debate. Preclinical data have suggested that metformin enhances PD-L1 anti-tumor effects in various cancer entities by decreasing insulin levels and inducing energetic stress. However, its impact on PD-L1 expression remains unclear in a clinical setting.
View Article and Find Full Text PDFObjective: Intradural spinal metastases are considered rare. At present, limited information is available on incidence, surgical management, and outcomes.
Methods: We conducted a retrospective patient chart review from 2002 to 2024, identifying all patients surgically treated for intradural spinal metastases.
Changes in management of head and neck malignancies during the COVID-19 pandemic.
Acta Otorhinolaryngol Ital
June 2024
Objective: Despite multiple studies from high-income countries, reports from low- and middle-income countries on the impact of COVID-19 on head and neck cancer care remain sparse. This study aimed to assess the effects of the COVID-19 pandemic on head and neck cancer patients at a tertiary reference centre in Bosnia and Herzegovina.
Methods: We included 228 patients with malignant head and neck tumours evaluated and treated between January 1, 2019, and December 31, 2021.