Publications by authors named "A D Lander"
Understanding the principles underlying the design of robust, yet flexible patterning systems is a key problem in developmental biology. In the wing, Hedgehog (Hh) signaling determines patterning outputs using dynamical properties of the Hh gradient. In particular, the pattern of () is established by the steady-state Hh gradient, whereas the pattern of (), is established by a transient gradient of Hh known as the Hh overshoot.
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- High dimensionality in single cell transcriptomics (scRNAseq) necessitates careful gene selection for effective analysis, particularly for tasks like cell clustering.
- Different feature selection methods yield varying performances depending on the analysis goals, with random features being sufficient for basic cell type identification but not for detecting subtle differences.
- The authors propose a new feature selection method that simplifies the process using an analytical model, enabling more accurate identification of rare cell types without relying on arbitrary parameters, and showing it outperforms standard methods like scanpy and Seurat.
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- IgA vasculitis (IgAV) is a common type of blood vessel disease in kids, and while most get better, some can have long-term kidney problems.
- A group of 28 experts worked for over a year to create guidelines on how to treat IgAV and its complications by reviewing many studies and getting feedback from others.
- The new guidelines have been approved by important health organizations and aim to help doctors provide better care for kids with this condition.
Background: Many approaches have been developed to overcome technical noise in single cell RNA-sequencing (scRNAseq). As researchers dig deeper into data-looking for rare cell types, subtleties of cell states, and details of gene regulatory networks-there is a growing need for algorithms with controllable accuracy and fewer ad hoc parameters and thresholds. Impeding this goal is the fact that an appropriate null distribution for scRNAseq cannot simply be extracted from data in which ground truth about biological variation is unknown (i.
View Article and Find Full Text PDFExposure to bright light can be visually aversive. This study explored the association between light aversion and various facets of impulsivity. A total of 1,245 participants completed the UPPS-Impulsive Behavior Scale to assess five facets of impulsivity.
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