Publications by authors named "A D Koryakina"
Article Synopsis
- * Researchers installed dental implants in rabbit tibias and compared the outcomes between those treated with MSC EVs and those without, observing significant increases in bone density (47.2%) at 3 days post-implantation in the MSC EV group.
- * By day 10, nearly complete fusion of the implant with bone was noted in the MSC EV treated group, while the control group displayed varying levels of osseointegration, indicating that MSC EVs enhance healing and integration of dental implants.
Article Synopsis
- Neonatal surgery is vital for reducing infant mortality from birth defects, which have long been a leading cause of early death.
- A study of neonatal deaths from 1995 to 2014 revealed that 77% of these cases were conditionally preventable, highlighting significant issues in healthcare organization.
- Implementing key strategies like better antenatal diagnosis, efficient transportation of newborns, centralizing care at advanced hospitals, and adopting modern treatment methods led to a 3.5 times decrease in mortality rates during the later study period (2005-2014).
Cryopreservation of human monocytes for pharmacopeial monocyte activation test.
J Immunol Methods
March 2014
EU Directive 2010/63/EU regarding the protection of experimental animals came into force in November 2010 with an obligation for EU member states to incorporate its requirements into their respective national legislations by 1st of January 2013. The directive stipulates the application of in vitro methods to replace animal experiments whenever such an in vitro method exits and is recognized by EU legislation. The monocyte activation test (MAT) for the detection and quantification of pyrogenic contamination in medicines is recognized by the European Directorate for the Quality of Medicines & Health Care (EDQM) and was published in the European Pharmacopeia (Pharm.
View Article and Find Full Text PDFSeparation and detection of all phosphoinositide isomers by ESI-MS.
J Pharm Biomed Anal
November 2010
Phosphoinositides (PIs) play fundamental roles as signalling molecules in numerous cellular processes. Direct analysis of PIs is typically accomplished by metabolic labelling with (3)H-inositol or inorganic (32)P followed by deacylation, ion-exchange chromatography and flow scintillation detection. This analysis is laborious, time-consuming, and involves massive amounts of radioactivity.
View Article and Find Full Text PDF(E,Z)-3-(3',5'-Dimethoxy-4'-hydroxy-benzylidene)-2-indolinone (indolinone) is an alkaloid that has been identified as a pharmacologically active compound in extracts of the traditional anti-inflammatory herb Isatis tinctoria. Indolinone has been shown to inhibit compound 48/80-induced mast cell degranulation in vitro. Application of indolinone to bone marrow derived mast cells showed that it was uniformly distributed in the cytoplasm and that cellular uptake was terminated within minutes.
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