Publications by authors named "A D Klimova"
Aim: The aim of the article is to summarize observations on cytomegalovirus (CMV) anterior uveitis, and in short case reports present cases of patients treated at our Department of Ophthalmology, First Faculty of Medicine, Charles University and General University Hospital in Prague.
Material And Methods: Retrospective analysis of patients at the Centre for diagnosis and treatment of uveitis from 2003 to 2024. Presentation of our experiences with CMV anterior uveitis confirmed by polymerase chain reaction (PCR) in aqueous humor in case reports.
Article Synopsis
- - This study focuses on new ionic liquids derived from imidazolium and choline containing 5-fluorouracil, exploring their effects on the structure and binding behavior with bovine serum albumin (BSA) using techniques like circular dichroism (CD) and fluorescence quenching.
- - The research investigates how the length of alkyl chains in these ionic liquids impacts their interaction with BSA and their aggregation tendencies through dynamic light scattering (DLS).
- - Results reveal that longer alkyl chains do not enhance binding to BSA, but one specific compound showed selectivity against cancer cells that regular 5-fluorouracil lacks, suggesting potential benefits in cancer treatment.
Introduction: Conducting a Medical Doctorate (MD) thesis is desired by the majority of medical students. However, the needed scientific competencies are not regularly implemented in medical education. To support students during their MD thesis, a graduate college was implemented.
View Article and Find Full Text PDFIntroduction: Small cell transformation (SCT) is a typical mechanism of adaptive resistance to third generation epidermal growth factor receptor inhibitors (EGFRi) which have become the standard of care for EGFR-driven non-small cell lung cancer (EGFR+ NSCLC). Little is known about the optimal management of SCT patients. This study aimed to compare outcomes under platinum/etoposide chemotherapy alone (chemo) or in combination with EGFR inhibitors (EGFRi+chemo) or immune checkpoint inhibitors (ICI+chemo).
View Article and Find Full Text PDFArticle Synopsis
- The study investigates how age and sex impact the prevalence and burden of primary headaches in children and adolescents at a pediatric headache center in Germany from 2015 to 2022.
- A total of 652 patients aged 3 to 18 were analyzed, revealing that nearly 60% were female, with the most common headache types being episodic migraine without aura and mixed-type headaches.
- Results indicate that headaches severely affected approximately 16% of children under 14 and increased to about 33% in adolescents, particularly impacting teenage girls.