Publications by authors named "A D Kahle"
Microglia play a critical role in maintaining central nervous system (CNS) homeostasis and display remarkable plasticity in their response to inflammatory stimuli. However, the specific signaling profiles that microglia adopt during such challenges remain incompletely understood. Traditional transcriptomic approaches provide valuable insights, but fail to capture dynamic post-translational changes.
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- The study investigates the effects of resting heart rate (RHR) on patients with heart failure who received implantable cardioverter-defibrillators (ICDs) or cardiac resynchronization therapy-defibrillators (CRT-Ds), specifically examining RHRs above and below 70 bpm.
- A total of 1589 patients were analyzed, and results showed that one-year all-cause mortality and major cardiovascular events were similar between those with RHR ≤ 70 bpm and > 70 bpm.
- However, patients with RHR > 70 bpm had higher rates of all-cause hospital admissions, mainly due to non-cardiovascular events, indicating potential increased risks associated with a higher RHR.
Background: Acutely effective repeated radiofrequency catheter ablation (RFCA) after previous atrial fibrillation ablation depends on several parameters including local impedance (LI), contact force (CF), and power.
Objective: We aimed to investigate the relationship of LI, CF, and power to the LI drop in a repeated atrial RFCA environment.
Methods: Consecutive patients undergoing repeated atrial RFCA were studied.
Microglia play a critical role in maintaining central nervous system (CNS) homeostasis and display remarkable plasticity in their response to inflammatory stimuli. However, the specific signaling profiles that microglia adopt during such challenges remain incompletely understood. Traditional transcriptomic approaches provide valuable insights, but fail to capture dynamic post-translational changes.
View Article and Find Full Text PDFObjective And Background: Data on incidence of in-hospital pulmonary embolisms (PE) after catheter ablation (CA) are scarce. To gain further insights, we sought to provide new findings through case-based analyses of administrative data.
Methods: Incidences of PE after CA of supraventricular tachycardias (SVT), atrial fibrillation (AF), atrial flutter (AFlu), and ventricular tachycardias (VT) in three German tertiary centers between 2005 and 2020 were determined and coded by the G-DRG (German Diagnosis Related Groups System) and OPS (German Operation and Procedure Classification) systems.